1204 Bharat Bhushan
22.1.2 Introduction to NEMS
NEMS are produced by nanomachining in a typical top-down approach (from
large to small) and bottom-up approach (from small to large), largely relying on
nanochemistry (see e.g., [39–45]). The NEMS field, in addition to fabrication of
nanosystems, has providedimpetus to the developmentof experimentaland compu-
tation tools. Examples of NEMS include microcantileverswith integratedsharp nan-
otipsfor STMand atomicforce microscopy(AFM) [46,47],quantumcorralsformed
using STM by placing atoms one by one [48], AFM cantilever arrays (Millipede)
fordata storage[49], STM andAFM tips for nanolithography,dip-pen nanolithogra-
phy for printing molecules, nanowires, carbon nanotubes, quantum wires (QWRs),
quantum boxes (QBs), quantum transistors [9], nanotube-based sensors [7,50], bio-
logical (DNA) motors, molecular gears made by attaching benzene molecules to the
outer walls of carbon nanotubes [8], devices incorporating nm-thick films [e.g., in
giant-magnetoresistive (GMR) read/write magnetic heads and magnetic media for
magnetic rigid disk and magnetic tape drives], nanopatterned magnetic rigid disks,
and nanoparticles(e.g., nanoparticles in magnetictape substrates and nanomagnetic
particles in magnetic tape coatings) [34,51]. More than 2 billion read/write mag-
netic heads were shipped for magnetic disk and tape drives in 2004.
Nanoelectronics can be used to build computer memory using individual mol-
ecules or nanotubes to store bits of information [52], molecular switches, molecular
or nanotube transistors, nanotube flat-panel displays, nanotube integrated circuits,
fast logic gates, switches, nanoscopic lasers, and nanotubes as electrodes in fuel
cells.
22.1.3 BioMEMS/BioNEMS
BioMEMS/BioNEMS are increasingly used in commercial and defense applica-
tions (see e.g., [53–60]). They are used for chemical and biochemical analyses
(biosensors) in medical diagnostics [e.g., DNA, ribonucleic acid (RNA), proteins,
cells, blood pressure and assays, and toxin identification] [60, 61], tissue engi-
neering [62–64], and implantable pharmaceutical drug delivery [65–67]. Biosen-
sors, also referred to as biochips, deal with liquids and gases. There are two
types. A large variety of biosensors are based on micro/nanofluidics [60,68–70].
Micro/nanofluidic devices offer the ability to work with smaller reagent volumes
and shorter reaction times, and perform multiple types of analysis at once. The
second type of biosensors include micro/nanoarrays, which perform one type of
analysis thousands of times [71–74].
A chip, called a lab-on-a-CD, with micro/nanofluidic technology embedded on
the disk can test thousands of biological samples rapidly and automatically [68]).
An entire laboratory can be integrated onto a single chip, called a lab-on-a-chip[60,
69, 70]. Silicon-based disposable blood-pressure sensor chips were introduced in
the early 1990sby GE NovaSensorfor blood-pressuremonitoring (about 25 million
units in 2004). A blood-sugar monitor, referred to as GlucoWatch, was introduced
in 2002. It automatically checks blood sugar every 10minutes by detecting glucose