
230 Section III • The Esophagus
STEP 2: PREOPERATIVE CONSIDERATIONS
◆ The word achalasia means “failure to relax,” which characterizes the pathophysiologic
dysfunction of the lower esophageal sphincter in this disease. The sustained high-pressure
zone is believed to be due to denervation or dysfunction of the nerves in Auerbach’s plexus,
which leads to the loss of inhibitory effects of these ganglia on the muscles of the lower
esophageal sphincter. Initiation of swallowing is normal; however, the esophagus cannot
empty properly, which leads to varying degrees of dysphagia. Typical symptoms include
odynophagia, foul breath, regurgitation of undigested food, and the patient describing a
sensation of food “getting stuck” in his or her lower chest. Late symptoms result from the
sequelae of continued aspiration and include hoarseness, pneumonitis, pneumonia, and
lung abscess.
◆ Diagnosis is based on patient symptoms and objective testing. Barium esophagram will
show a mild to severely dilated esophageal body with a characteristically smooth “bird-
beak” tapering at the distal esophagus. Manometry is the gold standard for diagnosis of
achalasia and will show a loss of propulsive contractions in the esophageal body. Resting
pressures at the lower esophageal sphincter can be normal to elevated with incomplete or
completely absent relaxation upon swallowing. Esophagoscopy with biopsy is sometimes
needed to rule out distal esophageal stricture due to esophagitis or carcinoma, which can
mimic achalasia.
◆ Once the diagnosis of achalasia is made, treatment usually begins with nonsurgical thera-
pies. Botulinum toxin injected via an endoscope into the area of the lower esophageal
sphincter can relieve symptoms in 50% to 65% of patients for as long as 18 months. Most
have recurrence of symptoms beyond this time. Pneumatic or forceful bougie dilation of
the lower esophageal sphincter has a long-term success rate approaching 70%. The gold
standard for treatment of achalasia is surgical myotomy, with long-term success rates of
90% to 95%. Patients are usually treated with one or two attempts of nonsurgical therapies
before being referred to a surgeon for myotomy. Those who are poor surgical candidates can
be treated nonsurgically indefi nitely.
◆ Informed consent is obtained from the patient who is given nothing by mouth 8 hours
before the procedure.
◆ General endotracheal anesthesia is administered for this procedure.
◆ The patient is placed in the lateral decubitus position with the right side down and secured
to the operating table. The bed can be bent at the seventh to eighth intercostal space to
facilitate exposure.
◆ The skin is prepped with povidone-iodine (Betadine), from the top of the shoulder
superiorly to the iliac crest inferiorly, then between the midline anteriorly and spinous
processes posteriorly.