Synthesis of gem-Difl uoromethylenated Nucleosides 211
cal difl uoromethylenation methodologies and more knowledge of structure – activity rela-
tionships, more effi cacious gem - difl uoromethylenated nucleosides will be developed as
novel antiviral and antitumor agents.
Acknowledgment
We are grateful to the National Natural Science Foundation of China, the Ministry of
Education of China and Shanghai Municipal Scientifi c Committee for the fi nancial
support.
References
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