Timbrell J. Principles of biochemical toxicology

Taylor & Francis is an imprint of the Taylor & Francis Group. This edition published in the Taylor & Francis e-Library, 2003.
ISBN 0-203-48417-7 Master e-book ISBN

Contents
Preface
CHAPTER 1 Introduction
Background
Scope
Biochemical aspects of toxicology
Summary
Review questions
Bibliography
CHAPTER 2 Dose-Response Relationships
Introduction
Criteria of toxicity
Dose-response
Measurement of dose-response relationships
Hazard and risk assessment
Chronic toxicity
Summary
Review questions
Bibliography
CHAPTER 3 Factors Affecting Toxic Responses: Disposition
Absorption
Sites of absorption
Distribution
Excretion
Summary
Review questions
Bibliography
CHAPTER 4 Factors Affecting Toxic Responses: Metabolism
Introduction
Types of metabolic change
Phase 1 reactions
Phase 2 reactions
Control of metabolism
Toxication versus detoxication
Summary
Review questions
Bibliography
CHAPTER 5 Factors Affecting Metabolism And Disposition
Introduction
Chemical factors
Biological factors
Summary
Review questions
Bibliography
CHAPTER 6 Toxic Responses To Foreign Compounds
Introduction
Direct toxic action: tissue lesions
Pharmacological, physiological and biochemical effects
Teratogenesis
Immunotoxicity
Genetic toxicity
Chemical carcinogenesis
Summary
Review questions
Bibliography
CHAPTER 7 Biochemical Mechanisms of Toxicity: Specific Examples
Chemical carcinogenesis
Tissue lesions: liver necrosis
Tissue lesions: kidney damage
Tissue lesions: lung damage
Neurotoxicity
Exaggerated and unwanted pharmacological effects
Physiological effects
Biochemical effects: lethal synthesis and incorporation
Biochemical effects: interaction with specific protein receptors
Teratogenesis
Immunotoxicity
Multi-organ toxicity
Multi-organ toxicity: metals
Summary
Review questions
Bibliography
Answers to review questions
Glossary
Index