Springer, 2006. - 523 p. - Understanding of the molecular basis of
DNA damage and its repair has increased dramatically in recent
years, and substantial knowledge now exists conceing the products
arising from free-radical attack on DNA. Free-radical DNA damage
may lead to mutations, cancer, and cell death. Free radicals have
various sources, notably ionizing radiation and oxidative stress.
In radiotherapy for cancer and with some anticancer drugs, use is
made of cell death by excessive DNA damage. The mechanisms leading
to products of free-radical attack which have been studied in
models and with small double-stranded DNA fragments are discussed
in detail, and the basics of the underlying free-radical chemistry
are dealt with in separate chapters.
Sonntag C. Free-Radical-Induced DNA Damage and Its Repair - A Chemical Perspective
- формат pdf
- размер 13.5 МБ
- добавлен 21 января 2012 г.
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