Arya D.P. (ed.) Aminoglycoside Antibiotics. From Chemical Biology to Drug Discovery

Wiley. 2007. 339 p.

Advances that open new avenues in developing aminoglycoside antibiotics
During the last twenty years, there have been numerous advances in the understanding of the chemistry, biochemistry, and recognition of aminoglycosides. This has led to the development of novel antibiotics and opened up new therapeutic targets for intervention. This is the first book to provide a complete overview of recent advances in the field and explore their tremendous potential for drug discovery and rational drug design. With chapters written by one or more leading experts in their specialty areas, the book addresses the chemistry, biology, and toxicology of aminoglycosides.

Contents

In the Beginning There Was Streptomycin
The Biochemistry and Genetics of Aminoglycoside Producers
Mechanisms of Aminoglycoside Antibiotic Resistance
Design, Chemical Synthesis, and Antibacterial Activity of Kanamycin and Neomycin Class Aminoglycoside Antibiotics
NMR Structural Studies of Aminoglycoside: RNA Interaction
Structural Comparisons Between Prokaryotic and Eukaryotic Ribosomal Decoding A Sites Free and Complexed with Aminoglycosides
Binding of Antibiotics to the Aminoacyl-tRNA Site of Bacterial Ribosome
Metalloaminoglycosides: Chemistry and Biological Relevance
Adverse Effects of Aminoglycoside Therapy
Targeting HIV-1 RNA with Aminoglycoside Antibiotics and Their Derivatives
Novel Targets for Aminoglycosides