experience altered sensory perception in the same areas, such as the sensa-
tion of crawling, tingling, burning, or pain. The progression of symptoms may
take hours or days.
Descending Guillain-Barré begins with muscles in the face, jaw, or throat
and travels downward. Respiratory compromise is a concern as the paralysis
reaches the level of the intercostal muscles and diaphragm. Breathing can
become compromised more quickly in patients with descending disease. Level
of consciousness, mental status, personality, and pupil size is not affected.
Patient support and monitoring are important during symptom progression.
Involvement of respiratory muscles may result in respiratory compromise or
failure. Involvement of ocular areas may cause blindness.
If the nerve cell body is damaged during the acute phase, there may be per-
manent deficits for the patient in the involved area. Otherwise, the axons of
the nerves may be able to repair the damage over several months.
Signs and Symptoms
䊋 Burning or pickling feeling due to demyelination of the nerve axons.
䊋 Symmetric weakness or flaccid paralysis, typically ascending in pattern.
䊋 Absence of deep tendon reflexes due to changes within the nerves: Reflexes
are a sensory-motor response that happen at the spinal level, not the brain.
䊋 Recent infection or other acute illness.
䊋 Facial weakness, dysphagia, visual changes in descending disease.
䊋 Labile blood pressure and cardiac dysrhythmias due to autonomic nerv-
ous system response.
Test Results
䊋 Lumbar puncture shows CSF with increased protein; may not be pres-
ent initially.
䊋 Nerve conduction studies show slowed velocity.
䊋 Pulmonary function tests show diminished tidal volume and vital capacity.
Treatment
䊋 Monitor respirations and support ventilation if necessary.
䊋 Plasmapheresis for plasma exchange to remove the antibodies in the cir-
culation.
䊋 Administer immunoglobulin IV after drawing labs for serum immunoglob-
ulin A.
䊋 Nasogastric tube feeding if swallowing is a problem.
Nursing Intervention
䊋 Monitor for progression of change of sensation.
䊋 Monitor respiratory status for change in effort or rate, use of accessory
muscles, cyanosis, change in breath sounds, breathlessness when talking,
irritability, decreased cognitive awareness.
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