Hermanson G. Bioconjugate Techniques, Second Edition
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1200 Index
Trinitrobenzenesulfonate , 175 ,
185
2,4,6-Trinitrobenzenesulfonate ,
see TNBS
N -(Triphenylmethyl)-3,4-
fulleropyrrolidine, 630
N -(Triphenylmethyl)-5
oxazolidinone, 631
Triphenylphosphine , 385 , 690 ,
691
reduction of azido groups
using, 385
Triphenylphosphine oxide , 690
Triple helix , 45
Triplet excited state , 399
Triplet-state ketone
intermediate, 328
Triplet transition , 399
Triplett , 218 , 222 , 763
Tris , 393 , 801
blocking excess glutaraldehyde
with, 913
for
blocking aldehydes , 166
blocking carboxylates
, 167
quenching glutaraldehyde
reactions, 798 , 800
in NHS ester reactions , 238
Tris(2-carboxyethyl)phosphine ,
see TCEP
2-[[Tris(hydroxymethyl)methyl]-
amino]ethanesulfonic acid ,
see TES
Tris(hydroxymethyl)phosphine ,
see THP
-[Tris(hydroxymethyl)-
phosphino] propionic acid ,
see THPP
Tris(hydroxymethyl)phosphino
propionic acid (THPP) , 180
TRITC , 416 , 419
comparison to Lissamine
rhodamine B , 422
silica particle embedded , 625
Triton X , 862
Trityl-oxazolidinone , 631
Trivedi , 423
tRNA , 51
, 410 , 514 , 971 , 973
Troponin ,
407
Troponin C , 260
Trotman , 1026
Trubetskoy , 500
Truneh , 882
Trypanosome brucia , 292
Trypsin , 97, 126, 181, 319, 339 ,
340, 649, 657, 665, 807, 1016
Trypsinogens , 126
Tryptic hydrolysis
of aminoethylated cysteine
residues, 119
Tryptophan , 6 , 900
oxidation by periodate , 393
absorptivity , 6
Tsai , 260
Tseng , 826
Tsien , 423
TSK3000 SW , 854
Tsomides , 551
TsT
activation of
mPEG using , 939
PEG using , 938
reactivity of , 938
toxicity of , 939
TsT-mPEG , 939
modifi cation of proteins with ,
940
Tsudo , 243
Tsukamoto , 101
Tsuro , 239
Tu , 971
Tubbs , 1025
Tuberculin purifi ed protein
derivative, 748
Tubulin
labeling with photobiotin , 531
Tullius , 1032
Tumor , 500 , 819 , 820 , 824 , 951
localization using avidin–
biotin interactions , 904
targeted with biotinylated
antibodies, 514
targeting
of , 498
with liposomes , 882
tumor antigens , 824
tumor necrosis factor , 247
Turecek , 653
Turko , 228
Tussen , 802
Tween , 20
CDI activation of , 641
Two-hybrid method , 1004
Two-phase systems , 938
Tyrosine , 7 , 25 , 102 , 103 , 126 ,
422 , 548 , 553 , 556
absorptivity , 10
iodination of , 548 , 549 , 551 ,
819
iodination reaction of , 203
modifi cation with H
2
OI , 547
nitrosation of , 25
oxidation of , 26
pKa , 11
radioiodination of , 498
reaction with
anhydrides , 178
diazonium , 272 , 273 , 773
diazonium group , 203
EDC , 218
isothiocyanates , 170
maleic anhydride , 159
p -aminobenzoyl biocytin,
diazotized, 534
tetranitromethane , 125
solvent exposed area , 30
use as an iodination scavenger ,
308
Tyrosine dimer , 1037
Tyrosine radical , 1037
Tyrosyl-lysine
conjugation
to BSA
, 757
with KLH using EDC , 757
Uchino , 430
Uchiumi , 256
Uchiyama , 1018
Uckun , 1016
Udupa , 1026
Ueland , 332
Ullman , 404
ULV , 754
Unilamellar vesicles , 860 , see
also ULV
Uracil , 51
cycloaddition to , 57
formation from cytosine , 55 ,
974
Index 1201
mercuration of , 57
reaction with CMC , 55
structure and reactivity , 54
Uraki , 158
Urdea , 996
Urea , 88 , 96 , 99
Urethane , 175 , 196 , 230 , 250 ,
454 , 579 , 941 , 946
Urge , 155
Uridine
biotin derivative of , 986
Uronic acid , 39 , 122
Uto , 284
UV irradiation , 277
Uyeda , 107 , 489
Vaccine , 22 , 745
, 747 ,
755
liposome containing , 858 ,
879
Valeric acid , 506 , 507 , 508 , 512 ,
522 , 524 , 526 , 529 , 531 ,
987 , 990
Valine , 5
solvent exposed area , 30
Valle , 103
Vallee , 773
van Belkum , 192
van Blaaderen , 623 , 625
van den Brink , 932
van der Horst , 305
Van der Tweel , 422 , 424
Van der Waals attraction , 925
Van der Waals distance , 531
van Dongen , 915
van Duren , 638
Van Lenten , 122 , 130
Van Regenmortel , 880
Vandelen , 243
VanDerVoort , 565 , 618
Vanim , 305
Vanin , 314
Varenne , 376
Varki , 151 , 152 , 538 , 539 , 540
Varlamov , 575
Varnavski , 389
Vashist , 492
Vasilescu , 1011
Vasoactive intestinal peptide ,
243 , 311
Vasoactive intestinal polypep-
tide
, 310
Vasoactive peptide , 247
Verhaegh ,
623
Verwey , 584 , 925
Vesicle , 863 , 868 , 888
encapsulation with haptens ,
881
iodoacetyl activated , 899
liposomal , 860 , 861
SPDP activated , 895
Vesicular stomatitis virus , 255
Vessières , 376
Vetter , 149 , 150 , 368
Vibrio cholerae , 132
VICAT mass tag , 655
Vigers , 404 , 421
Vilja , 514
Vincent ,
126 , 774
Vinyl addition , 134
Vinylsulfone
reaction with thiols ,
188
Virus , 746 , 747
Viscidi , 976
Vitamin H , 900 , see also
Biotin
Vithayathil , 109 , 183
Vivagel , 367
Vliegenthart , 48
Vogel , 824 , 834 , 848 , 850 , 857
Vogelbacker , 380
von der Haar , 980
Vrij , 623 , 625
Wade , 526
Waggoner , 400
, 465
Wagoner , 423
Wakil , 101
Waldeck , 62
Waldmann
, 498
Wallace , 311
Wallach , 262
Wallenfels , 964
Walling , 205 , 328
Walus , 302
Wang , 119 , 254 , 256 , 427 , 574 ,
620 , 629
Wang and Richards ’ reagent , see
DTBP
Ward , 243 , 256 , 258 , 826
Ware , 407
Warner , 400
Warwood , 181
Water
as nucleophile , 103
relative nucleophilicity , 43
Waterman ,
252
Watson , 818
Watson–Crick model
of DNA , 64
Waugh , 241 , 243 , 249
Weaver , 965
Weber , 296 , 818
Wedekind , 336 , 510
Wei , 708
Weil , 964
Weisgras , 974
Weith , 211 , 676
Welch , 498
Wells , 256 , 258 , 347
Weltman , 288
Wensel , 482
Wessels , 498
Wessendorf , 422
Weston , 81
Wetlaufer , 164
Wheat , 754
Whetstone , 657
Whitaker , 453
White phosphorus
reduction of chloroauric acid
with , 928
Whitesides , 189 , 590 , 709
Wieder , 939
Wiels , 834
Wiesner , 625
Wijnen , 667
Wilbur , 176 , 251 , 376 , 379 , 546 ,
549 , 559 , 561 , 710
Wilchek , 122 , 130 , 132 , 139 ,
142 , 256 ,
270 , 271 , 275 ,
423 , 508 , 529 , 535 , 606 ,
610 , 612 , 614 , 671 , 735 ,
901 , 913 , 915 , 919 , 943 ,
945 , 968 , 989
Wiley , 255 , 677 , 678
Willey , 189
Williams
, 124 , 177 , 216 , 965
Willingham , 256
1202 Index
Willner , 824 , 847
Wilson , 112 , 232 , 366 , 807
Winterbourn , 23 , 28
Winzerling , 575
Wirth , 950
Wittig , 421
Wöhnert , 485
Wojchowski , 904
Wold , 234 , 250 , 252 , 260 , 395
Wolf , 1039
Wolff rearrangement , 207
of diazopyruvates , 322
Wollenweber , 306
Woller , 366 , 371
Wong , 170 , 199 , 328
Wood , 158 , 243 , 247 , 310 , 311
Woodward , 148 , 228
Woodward’s reagent K
general description and use , 228
Wright , 243 , 531
Wu , 69 , 83 , 351 , 492 , 498 , 521
Wyckoff , 963
Wygrecka , 209 , 533
Xiao , 492
Xu , 695 , 701
Xylene cylanol , 403
Xylose , 38
Yalpani , 328
Yamada , 216
Yamamoto , 525
Yamasaki , 333
Yan , 205 , 303 , 651 , 1018
Yanagita , 254
Yang , 239 , 247 , 256 , 410 , 413
Yanhioglu , 484
Yano , 319
Yao , 492 , 620 , 623
Yasuda , 879
Yeast , 857
Yegneswaran , 427
Yem , 185
Yen , 612
Yeo , 705
Yeung , 310
Yokota , 930
Yoo , 381 , 383
Yoon , 385
Yoshitake , 94 , 284 , 792
Youle , 287 , 852
Young , 225 , 255
Yttrium-9 , 498
Yttrium-88 , 498
Yu , 255 , 638
Yurchenko , 1026
Zahling , 260
Zahn , 175 , 256 , 258 , 260
Zakharian , 634 , 648
Zalipsky , 939 , 941 , 943
Zanocco , 124 , 146 , 981
Zappacosta , 650 , 665
Zara
, 301
Zarling , 246 , 316 , 395
Zecherle , 257
Zeheb , 516
Zero-length crosslinking agents ,
176 , 215 , 228 , 231 , 723 ,
855 , 1037 , see also Cross-
linker, zero-length
Zhang , 292 , 651 , 702
Zhao , 620 , 625 , 626 , 953
Zheng , 389
Zhong , 143
Zhou , 576 , 641 , 655
Zhu , 292
Zinc , 963
Zlateva , 951
Zola , 462
, 919
Zopf , 41 , 774
Zsigmondy , 924 , 928