PROBLEM 8-1
Suppose a new cholesterol-lowering drug comes on the market. If the drug is
to be approved by the government for public use, it must be shown effective,
and it must also be shown not to have too many serious side effects. So it is
tested. During the course of testing, 10,000 people, all of whom have been
diagnosed with high cholesterol, are given this drug. Imagine that 7289 of
the people experience a significant drop in cholesterol. Also suppose that
307 of these people experience adverse side effects. If you have high choles-
terol and go on this drug, what is the empirical probability p
emp
(B) that
you will derive benefit? What is the empirical probability p
emp
(A) that you
will experience adverse side effects?
SOLUTION 8-1
Some readers will say that this question cannot be satisfactorily answered
because the experiment is not good enough. Is 10,000 test subjects a large
enough number? What physiological factors affect the way the drug works?
How about blood type, for example? Ethnicity? Gender? Blood pressure?
Diet? What constitutes ‘‘high cholesterol’’? What constitutes a ‘‘significant
drop’’ in cholesterol level? What is an ‘‘adverse side effect’’? What is the
standard drug dose? How long must the drug be taken in order to know if
it works? For convenience, we ignore all of these factors here, even though,
in a true scientific experiment, it would be an excellent idea to take them all
into consideration.
Based on the above experimental data, shallow as it is, the relative
frequency of effectiveness is 7289/10,000 ¼ 0.7289 ¼ 72.89%. The relative
frequency of ill effects is 307/10,000 ¼ 0.0307 ¼ 3.07%. We can round these
off to 73% and 3%. These are the empirical probabilities that you will derive
benefit, or experience adverse effects, if you take this drug in the hope of
lowering your high cholesterol. Of course, once you actually use the drug,
these probabilities will lose all their meaning for you. You will eventually say
‘‘The drug worked for me’’ or ‘‘The drug did not work for me.’’ You will say,
‘‘I had bad side effects’’ or ‘‘I did not have bad side effects.’’
REAL-WORLD EMPIRICISM
Empirical probability is used by scientists to make predictions. It is not good
for looking at aspects of the past or present. If you try to calculate the empiri-
cal probability of the existence of extraterrestrial life in our galaxy, you can
play around with formulas based on expert opinions, but once you state a
numeric figure, you commit the PF. If you say the empirical probability
that a hurricane of category 3 or stronger struck the US mainland in 1992
CHAPTER 8 Taking Chances 171