
AN APPLICATION TO BIOLOGICAL FLUID DYNAMICS: FLOW IN AN ELASTIC TUBE 139
separately for each equation in a sequential manner. The application that we con-
sider here consists of a generic elastic tube of reference length L = 25 cm. We
use fluid properties relevant to human blood, such as density, ρ = 1.06 g/cm
3
;
viscosity, μ = 0.049 poise. The reference pressure is set to p
0
= 80 mmHg.
The proximal boundary condition for pressure, p
L
(t), is time varying while
the distal boundary condition is fixed at 15 mmHg. The reference pressure p
0
represents the approximate maximum pressure in the system. Velocity boundary
conditions are obtained by zeroth-order extrapolation at both ends of the vessel.
We adopt an approximate equation of state, S (p, z):
S (p, z) = 7.07e
−0.25z+(p−p
0
)/ρc(p, z )c(p
0
, z )
(2.13.39)
It is apparent that this expression depends on c, the wave speed in the fluid.
Assuming that c is a product of linear functions of both z and p andisinunits
of cm/s, an equation for this quantity can be written as (Anliker et al., 1971)
c(p, z) = (97 + 2.03p)(1 +0.02z) (2.13.40)
The pulsating flow in the elastic tube is assumed to be laminar and unsteady,
so that the friction term, f , can be written using Poiseuille’s formula for circular
pipes:
f
laminar
=−8π
μ
ρ
V
S
(2.13.41)
This equation will approximate viscous effects in the vessel and is assumed valid
for both steady and unsteady flow.
Initial conditions are less important because after a few initial cycles driven
by the proximal boundary conditions, the solution reaches quasi-steady state
independent of the initial conditions. If the initial conditions are not too different
than the final solution, the computation time to reach quasi steady state will
decrease. For this computation, we implemented the following initial conditions:
V = V
L
e
z
25
ln
V
R
V
L
(2.13.42)
p = p
L
e
z
25
ln
V
R
V
L
(2.13.43)
Here, V
R
= 0.1cm/s,V
L
= 3.0cm/s,p
R
= 15 mmHg, and p
L
is obtained from
the proximal boundary condition for pressure.
The axial z direction is discretized with 100 points, corresponding to a grid
spacing of z = 0.25. We impose a forcing pressure pulse of about 86 beats per
minute through the proximal boundary condition. The signal is interpolated by
a cubic spline to provide the value of the left boundary condition for pressure