PREPUBLICATION COPY: UNCORRECTED PROOFS !
PREPUB
ISBN-10: 0-309-21944-2
ISBN-13: 978-0-309-21944-0
Contents
summary
Charge to the Committee
Assessing the Weight of Evidence
Causality Assessment
Causality Conclusions
Susceptibility
Concluding Comment
References
ntroduction
Charge to the Committee
Committee Process
Outline of the Report
References
Approach
Literature Searching
Weight of Evidence
Causality Assessment
Special Considerations
References
Evaluating biological mechanisms of adverse events
Latency Between Antigen Exposure and Peak Adaptive Immune Response
mmune-Mediated Mechanisms
ral Activity
njection-Related Adverse Events
Coagulation and Hypercoagulable States
ncreased Susceptibility
Alterations in Brain Development
Contribution of Animal Models
References
Measles, Mumps, And rubella vaccine
ntroduction
Measles Inclusion Body Encephalitis
Encephalitis and Encephalopathy
Febrile Seizures
Afebrile Seizures
Meningitis
Ataxia
Autism
Acute Disseminated Encephalomyelitis
Transverse Myelitis
Optic Neuritis
Neuromyelitis Optica
Multiple Sclerosis Onset in Adults
Multiple Sclerosis Onset in Children
Guillain-Barr? Syndrome
Chronic Inflammatory Disseminated Polyneuropathy
Opsoclonus Myoclonus Syndrome
Brachial Neuritis
Anaphylaxis
Transient Arthralgia in Women
Transient Arthralgia in Children
Chronic Arthralgia in Women
Chronic Arthritis in Women
Chronic Arthropathy in Children
Arthropathy in Men
Type 1 Diabetes
Hepatitis
Chronic Fatigue Syndrome
Fibromyalgia
Hearing Loss
References
aricella virus vaccine
ntroduction
Disseminated Oka Vzv without Other Organ Involvement
Disseminated Oka Vzv with Other Organ Involvement
accine Strain Viral Reactivation Without Other Organ Involvement
accine Strain Viral Reactivation with Other Organ Involvement
Encephalopathy
Seizures
Cerebellar Ataxia
Acute Disseminated Encephalomyelitis
Transverse Myelitis
Guillain-Barr? Syndrome
Small Fiber Neuropathy
Anaphylaxis
Onset or Exacerbation of Arthropathy
Stroke
Thrombocytopenia
References
nfluenza vaccine
ntroduction
Encephalitis and Encephalopathy
Seizures
Acute Disseminated Encephalomyelitis
Transverse Myelitis
Optic Neuritis
Neuromyelitis Optica
Multiple Sclerosis Onset in Adults
Multiple Sclerosis Relapse in Adults
Guillain-Barr? Syndrome
Chronic Inflammatory Disseminated Polyneuropathy
Bell’s Palsy
Brachial Neuritis
Small Fiber Neuropathy
Anaphylaxis
nactivated Influenza Vaccine and Asthma Exacerbation or Reactive Airway Disease
Episodes in Children and Adults
Live Attenuated Influenza Vaccine and Asthma Exacerbation or Reactive Airway Disease
Episodes in Children Younger Than 5 Years of Age
Live Attenuated Influenza Vaccine and Asthma Exacerbation or Reactive Airway Disease
Episodes in Persons 5 Years of Age or Older
Onset or Exacerbation of Systemic Lupus Erythematosus
Onset or Exacerbation of Vasculitis
Polyarteritis Nodosa
Onset or Exacerbation of Arthropathy
Stroke
Myocardial Infarction
Fibromyalgia
All-Cause Mortality
Oculorespiratory Syndrome
References
Hepatitis a vaccine
ntroduction
Acute Disseminated Encephalomyelitis
Transverse Myelitis
Multiple Sclerosis
Guillain-Barr? Syndrome
Chronic Inflammatory Disseminated Polyneuropathy
Bell’s Palsy
Anaphylaxis
Autoimmune Hepatitis
References
Hepatitis b vaccine
ntroduction
Encephalitis and Encephalopathy
Seizures
Acute Disseminated Encephalomyelitis
Transverse Myelitis
Optic Neuritis
Neuromyelitis Optica
Multiple Sclerosis Onset in Adults
Multiple Sclerosis Onset in Children
Multiple Sclerosis Relapse in Adults
Multiple Sclerosis Relapse in Children
First Demyelinating Event in Adults
First Demyelinating Event in Children
Guillain-Barr? Syndrome
Chronic Inflammatory Disseminated Polyneuropathy
Brachial Neuritis
Anaphylaxis
Erythema Nodosum
Onset or Exacerbation of Systemic Lupus Erythematosus
Onset or Exacerbation of Vasculitis
Onset or Exacerbation of Polyarteritis Nodosa
Onset or Exacerbation of Psoriatic Arthritis
Onset or Exacerbation of Reactive Arthritis
Onset or Exacerbation of Rheumatoid Arthritis
Onset or Exacerbation of Juvenile Idiopathic Arthritis
Type 1 Diabetes
Fibromyalgia
References
Human papillomavirus vaccine
ntroduction
Acute Disseminated Encephalomyelitis
Transverse Myelitis
Neuromyelitis Optica
Multiple Sclerosis
Guillain-Barr? Syndrome
Chronic Inflammatory Disseminated Polyneuropathy
Brachial Neuritis
Amyotrophic Lateral Sclerosis
Transient Arthralgia
Pancreatitis
Thromboembolic Events
Hypercoagulable States
References
Diphtheria toxoid-, Tetanus toxoid-, And acellular pertussiscontaining
accines
ntroduction
Encephalitis and Encephalopathy
nfantile Spasms
Seizures
Ataxia
Autism
Acute Disseminated Encephalomyelitis
Transverse Myelitis
Optic Neuritis
Multiple Sclerosis Onset in Adults
Multiple Sclerosis Relapse in Adults
Multiple Sclerosis Relapse in Children
Guillain-Barr? Syndrome
Chronic Inflammatory Disseminated Polyneuropathy
Opsoclonus Myoclonus Syndrome
Bell’s Palsy
Anaphylaxis
Chronic Urticaria
Serum Sickness
Arthropathy
Type 1 Diabetes
Myocarditis
Fibromyalgia
Sudden Infant Death Syndrome
mmune Thrombocytopenic Purpura
References
Meningococcal vaccine
ntroduction
Encephalitis and Encephalopathy
Acute Disseminated Encephalomyelitis
Transverse Myelitis
Multiple Sclerosis
Guillain-Barr? Syndrome
Chronic Inflammatory Disseminated Polyneuropathy
Anaphylaxis
Chronic Headache
References
njection-Related adverse events
Complex Regional Pain Syndrome
Deltoid Bursitis
Syncope
References
Concluding comments
References
Appendixes
A glossary
B LIST OF ADVERSE EVENTS
C LITERATURE SEARCH STRATEGY
D CAUSALITY CONCLUSION TABLES
E REFERENCES
F COMMITTEE BIOSKETCHES
G MEETING AGENDAS
PREPUB
ISBN-10: 0-309-21944-2
ISBN-13: 978-0-309-21944-0
Contents
summary
Charge to the Committee
Assessing the Weight of Evidence
Causality Assessment
Causality Conclusions
Susceptibility
Concluding Comment
References
ntroduction
Charge to the Committee
Committee Process
Outline of the Report
References
Approach
Literature Searching
Weight of Evidence
Causality Assessment
Special Considerations
References
Evaluating biological mechanisms of adverse events
Latency Between Antigen Exposure and Peak Adaptive Immune Response
mmune-Mediated Mechanisms
ral Activity
njection-Related Adverse Events
Coagulation and Hypercoagulable States
ncreased Susceptibility
Alterations in Brain Development
Contribution of Animal Models
References
Measles, Mumps, And rubella vaccine
ntroduction
Measles Inclusion Body Encephalitis
Encephalitis and Encephalopathy
Febrile Seizures
Afebrile Seizures
Meningitis
Ataxia
Autism
Acute Disseminated Encephalomyelitis
Transverse Myelitis
Optic Neuritis
Neuromyelitis Optica
Multiple Sclerosis Onset in Adults
Multiple Sclerosis Onset in Children
Guillain-Barr? Syndrome
Chronic Inflammatory Disseminated Polyneuropathy
Opsoclonus Myoclonus Syndrome
Brachial Neuritis
Anaphylaxis
Transient Arthralgia in Women
Transient Arthralgia in Children
Chronic Arthralgia in Women
Chronic Arthritis in Women
Chronic Arthropathy in Children
Arthropathy in Men
Type 1 Diabetes
Hepatitis
Chronic Fatigue Syndrome
Fibromyalgia
Hearing Loss
References
aricella virus vaccine
ntroduction
Disseminated Oka Vzv without Other Organ Involvement
Disseminated Oka Vzv with Other Organ Involvement
accine Strain Viral Reactivation Without Other Organ Involvement
accine Strain Viral Reactivation with Other Organ Involvement
Encephalopathy
Seizures
Cerebellar Ataxia
Acute Disseminated Encephalomyelitis
Transverse Myelitis
Guillain-Barr? Syndrome
Small Fiber Neuropathy
Anaphylaxis
Onset or Exacerbation of Arthropathy
Stroke
Thrombocytopenia
References
nfluenza vaccine
ntroduction
Encephalitis and Encephalopathy
Seizures
Acute Disseminated Encephalomyelitis
Transverse Myelitis
Optic Neuritis
Neuromyelitis Optica
Multiple Sclerosis Onset in Adults
Multiple Sclerosis Relapse in Adults
Guillain-Barr? Syndrome
Chronic Inflammatory Disseminated Polyneuropathy
Bell’s Palsy
Brachial Neuritis
Small Fiber Neuropathy
Anaphylaxis
nactivated Influenza Vaccine and Asthma Exacerbation or Reactive Airway Disease
Episodes in Children and Adults
Live Attenuated Influenza Vaccine and Asthma Exacerbation or Reactive Airway Disease
Episodes in Children Younger Than 5 Years of Age
Live Attenuated Influenza Vaccine and Asthma Exacerbation or Reactive Airway Disease
Episodes in Persons 5 Years of Age or Older
Onset or Exacerbation of Systemic Lupus Erythematosus
Onset or Exacerbation of Vasculitis
Polyarteritis Nodosa
Onset or Exacerbation of Arthropathy
Stroke
Myocardial Infarction
Fibromyalgia
All-Cause Mortality
Oculorespiratory Syndrome
References
Hepatitis a vaccine
ntroduction
Acute Disseminated Encephalomyelitis
Transverse Myelitis
Multiple Sclerosis
Guillain-Barr? Syndrome
Chronic Inflammatory Disseminated Polyneuropathy
Bell’s Palsy
Anaphylaxis
Autoimmune Hepatitis
References
Hepatitis b vaccine
ntroduction
Encephalitis and Encephalopathy
Seizures
Acute Disseminated Encephalomyelitis
Transverse Myelitis
Optic Neuritis
Neuromyelitis Optica
Multiple Sclerosis Onset in Adults
Multiple Sclerosis Onset in Children
Multiple Sclerosis Relapse in Adults
Multiple Sclerosis Relapse in Children
First Demyelinating Event in Adults
First Demyelinating Event in Children
Guillain-Barr? Syndrome
Chronic Inflammatory Disseminated Polyneuropathy
Brachial Neuritis
Anaphylaxis
Erythema Nodosum
Onset or Exacerbation of Systemic Lupus Erythematosus
Onset or Exacerbation of Vasculitis
Onset or Exacerbation of Polyarteritis Nodosa
Onset or Exacerbation of Psoriatic Arthritis
Onset or Exacerbation of Reactive Arthritis
Onset or Exacerbation of Rheumatoid Arthritis
Onset or Exacerbation of Juvenile Idiopathic Arthritis
Type 1 Diabetes
Fibromyalgia
References
Human papillomavirus vaccine
ntroduction
Acute Disseminated Encephalomyelitis
Transverse Myelitis
Neuromyelitis Optica
Multiple Sclerosis
Guillain-Barr? Syndrome
Chronic Inflammatory Disseminated Polyneuropathy
Brachial Neuritis
Amyotrophic Lateral Sclerosis
Transient Arthralgia
Pancreatitis
Thromboembolic Events
Hypercoagulable States
References
Diphtheria toxoid-, Tetanus toxoid-, And acellular pertussiscontaining
accines
ntroduction
Encephalitis and Encephalopathy
nfantile Spasms
Seizures
Ataxia
Autism
Acute Disseminated Encephalomyelitis
Transverse Myelitis
Optic Neuritis
Multiple Sclerosis Onset in Adults
Multiple Sclerosis Relapse in Adults
Multiple Sclerosis Relapse in Children
Guillain-Barr? Syndrome
Chronic Inflammatory Disseminated Polyneuropathy
Opsoclonus Myoclonus Syndrome
Bell’s Palsy
Anaphylaxis
Chronic Urticaria
Serum Sickness
Arthropathy
Type 1 Diabetes
Myocarditis
Fibromyalgia
Sudden Infant Death Syndrome
mmune Thrombocytopenic Purpura
References
Meningococcal vaccine
ntroduction
Encephalitis and Encephalopathy
Acute Disseminated Encephalomyelitis
Transverse Myelitis
Multiple Sclerosis
Guillain-Barr? Syndrome
Chronic Inflammatory Disseminated Polyneuropathy
Anaphylaxis
Chronic Headache
References
njection-Related adverse events
Complex Regional Pain Syndrome
Deltoid Bursitis
Syncope
References
Concluding comments
References
Appendixes
A glossary
B LIST OF ADVERSE EVENTS
C LITERATURE SEARCH STRATEGY
D CAUSALITY CONCLUSION TABLES
E REFERENCES
F COMMITTEE BIOSKETCHES
G MEETING AGENDAS