CRC Press,Taylor & Francis,London, 2002. — 448 pages.
Монография посвящена многочисленным функциям и роли ГАМК – и
глютаматергической систем в нормальной и патологической физиологии
головного мозга. Описание входящих в обе системе рецепторных
структур удовлетворит самого взыскательного исследователя посколько
выполнено на современном молекулярно биологическом уровне.
Проанализированы механизмы реализующие транспорт ГАМК и глютамата в
глиальной и ткани и нейронах. Чрезвычайно интересны данные
полученые на трансгенных лабораторных животных. Книга не оставит
равнодушными фармакологов, нейрохимиков и нейрофизиологов. А
подробно описанные возможности фармакологического управления обеими
системами и приведенные клинико-биохимические корреляции при
различных патологически состояниях заинтересуют и увлеченного
клинициста.
Содержание.
Ionotropic glutamate receptors
Functional and pharmacological properties in relation to constituent subunits.
Structure of ionotropic glutamate receptors.
Glutamate receptor trafficking.
Pharmacology of NMDA Receptors.
Pharmacology of AMPA/kainate Receptors.
Metabotropic glutamate Receptors.
Metabotropic glutamate receptors (mGluRs)
Structure and function.
Pharmacology of metabotropic glutamate receptors.
GABAA receptors.
Insights into GABAA receptor complexity from the study of cerebellar granule cells
Synaptic and extrasynaptic receptors.
GABAA receptor complex
Structure and function.
Ligands for the GABAA receptor Complex.
Metabotropic GABA Receptors.
Molecular structure of the GABAB receptors.
Pharmacology of GABAB Receptors.
Glutamate and GABA Transporters.
Structure, function and regulation of glutamate transporters.
GABA transporters: Functional and pharmacological properties.
Pathophysiology and therapeutic prospects.
Transgenic models for glutamate receptor function.
Transgenic models for GABAA-receptor function.
Glutamatergic transmission
Therapeutic prospects for schizophrenia and Alzheimer’s disease.
Modulators of the GABAA receptor
Novel therapeutic prospects.
Functional and pharmacological properties in relation to constituent subunits.
Structure of ionotropic glutamate receptors.
Glutamate receptor trafficking.
Pharmacology of NMDA Receptors.
Pharmacology of AMPA/kainate Receptors.
Metabotropic glutamate Receptors.
Metabotropic glutamate receptors (mGluRs)
Structure and function.
Pharmacology of metabotropic glutamate receptors.
GABAA receptors.
Insights into GABAA receptor complexity from the study of cerebellar granule cells
Synaptic and extrasynaptic receptors.
GABAA receptor complex
Structure and function.
Ligands for the GABAA receptor Complex.
Metabotropic GABA Receptors.
Molecular structure of the GABAB receptors.
Pharmacology of GABAB Receptors.
Glutamate and GABA Transporters.
Structure, function and regulation of glutamate transporters.
GABA transporters: Functional and pharmacological properties.
Pathophysiology and therapeutic prospects.
Transgenic models for glutamate receptor function.
Transgenic models for GABAA-receptor function.
Glutamatergic transmission
Therapeutic prospects for schizophrenia and Alzheimer’s disease.
Modulators of the GABAA receptor
Novel therapeutic prospects.