Vlak J.M., de Gooijer C.D., Tramper J., Miltenburger H.G. (Eds.) Insect Cell Cultures: Fundamental and Applied Aspects
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F. Hoffmann-La Roche Ltd.
Pharmaceutical Research
Preclinical Biotechnology, Bldg. 66/108
CH-4070 BASEL, SWITZERLAND
Phone: 41-61-688-5465
Fax: 41-61-688-1448
Part II: Viruses
7. Baculovirus–insect cell interactions
Gary W. Blissard
Boyce Thompson Institute for Plant Research
Cornell University
Tower Road
ITHACA, NY 14853-1801, U.S.A.
Phone:
1-607-254-1366
Fax: 1-607-254-1242
E-mail: gwbl@cornell.edu
8. Replication patterns and cytopathology of cells
infected with baculoviruses
Greg V. Williams and Peter Faulkner
Department of Microbiology and Immunology
Queen’s University
KINGSTON
Ontario K7L 3NG, CANADA
Phone: 1-613-545-2464
Fax: 1-613-545-6796
E-mail: faulknrp @ quedn.queensu.ca
9. Construction of baculovirus recombinants
Paul A. Kitts
CLONTECH Laboratories, Inc.
1020 East Meadow Circle
PALO ALTO, CA 94303-4230, U.S.A.
Phone: 1-415-424-8222, ext. 415
Fax: 1-415-424-1064
E-mail: paulki@clontech.com
10. Passage effect of virus infection in insect cells
Peter J. Krell
Department of Microbiology
College of Biological Sciences
University of Guelph
GUELPH
Ontario N1G 2W1, CANADA
Phone: 519-824-4120, ext. 3368
Fax: 519-837-1802
E-mail: pkrell @ uoguelph.ca
11. Post-translational modifications in insect cells
Hans-Dieter Klenk
Institute of Virology
Phillips University Marburg
Postfach 2360
D-35011 MARBURH (Lahn), GERMANY
Phone: 49-6421-28-6253
Fax: 49-6421-28-8962
E-mail: klenk @ vax.hrz.uni-marburg.de
12. Productivity of insect cells for recombinant
proteins
James E. Maruniak
Department of Entomology
University of Florida
GAINESVILLE, FL 32611-0740, U.S.A.
Phone: 1-904-392-1790, ext. 148
Fax: 1-904-392-0190
E-mail: jmarun@nervm.nerdc.ufl.edu
13. Chaperone and foldase coexpression in the
baculovirus-insect cell expression system
Michael J. Betenbaugh, Eric Ailor, Erik Whiteley,
Paul Hinderliter and Tsu-An Hsu
Department of Chemical Engineering
The Johns Hopkins University
BALTIMORE, MD 21218-2694, U.S.A.
Phone: 1-410-516-5461
Fax: 1-410-516-5510
E-mail: beten@jhuvma.hof.jhu.edu
Part III: Engineering aspects
14. Shear sensitivity of insect cells
Jeffrey J. Chalmers
Department of Chemical Engineering
The Ohio State University
121 Koffolt Laboratories
140 West 19th Avenue
COLUMBUS, OH 43210-1180, U.S.A.
Phone: 1-614-292-6591
Fax: 1-614-292-3769
15. Insect cell bioreactors
Spiros N. Agathos
Unit of Bioengineering
Catholic University of Louvain
Place Croix du Sud 2/19
B-1348 LOUVAIN-LA-NEUVE, BELGIUM
Phone: 32-10-47-3644
Fax: 32-10-47-3062
E-mail: agathos@gebi.ucl.ac.be
16. Perfusion bioreactors for the production of
recombinant proteins in insect cells
Volker Jäger
Cell Culture Techniques Department
Gesellschaft für Biotechnologische Forschung
Mascheroder Weg 1
D-38124 BRAUNSCHWEIG, GERMANY
Phone: 49-531-6181-102
Fax: 49-531-6181-488
E-mail: vja @ ghf-braunschweig.de
17. Immobilization of insect cells
Jian-Yong Wu and Matheus F.A. Goosen
Department of Chemical Engineering
Queen’s University
KINGSTON
Ontario K7L 3NL, CANADA
Phone: 613-545-2782
Fax: 613-545-6637
E-mail: goosenm@quedn.queens.ca
18. Modelling baculovirus infection of insect cell
culture
John F. Power and Lars K. Nielsen
Department of Chemical Engineering
The University of Queensland
ST. LUCIA 4027
Queensland, AUSTRALIA
Phone: 61-2-899-2111
Fax: 61-2-899-2151
19. Scale up aspects of sparged insect-cell
bioreactors
Johannes Tramper
1
, Just M. Vlak
2
and C.D. de
Gooijer
1
1
Department of Food Science
Food and Bioprocess Engineering Group
Wageningen Agricultural University
Bomenweg 2
6703 HD WAGENINGEN, THE NETHER-
LANDS
Phone: 31-317-483204
Fax: 31-317-482237
E-mail:hans.tramper @ medew.prock. wau.nl
2
Department of Virology Wageningen Agricultural
University
Binnenhaven 11
6709 PD WAGENINGEN,THE NETHERLANDS
Phone: 31-317-483090
Fax: 31-317-484820
E-mail: just, vlak @ medew.viro.wau.nl
20. Oxygen gradiengs in small and big sparged
insect cell reactors
Johannes Tramper
1
, Just M. Vlak
2
and C.D. de
Gooijer
1
1
Department of Food Science
Food and Bioprocess Engineering Group
Wageningen Agricultural University
Bomenweg 2
6703 HD WAGENINGEN, THE NETHER-
LANDS
Phone: 31-317-483204
Fax: 31-317-482237
E-mail:hans.tramper @ medew.prock. wau.nl
2
Department of Virology Wageningen Agricultural
University
Binnenhaven 11
6709 PD WAGENINGEN,THE NETHERLANDS
Phone: 31-317-483090
Fax: 31-317-484820
E-mail: just, vlak @ medew.viro.wau.nl
21. Down-stream processing of insect cell cultures
Alain R. Bernard, Manjula Lusti-Narasimhan,
Kathryn M. Radford, Richard S. Hale, Eric Sebille
and Pierre Graber
Department of Fermentation
Glaxo Institute for Molecular Biology, S.A.
14, Chemin des Aulx
1228 Plan-les-Ouates
GENEVA, SWITZERLAND
Phone: 41-22-706-9642
Fax: 41-22-794-6965
E-mail: arbo575@ggr.co.uk
Part IV: Applications
22. Parvovirus diagnostics and vaccine production
in insect cells
J. Ignacio Casal
Immunologia y Genetica Aplicade, S.A.
INGENASA
Hermanos García Noblejas, 41-2
28037 MADRID, SPAIN
Phone: 34-1-368-0501
Fax: 34-1-408-7598
23. Classical swine fever virus diagnostics and
vaccine production in insect cells
Marcel M. Hulst and Rob J.M. Moormann
Centraal Diergeneeskundig Instituut/DLO
Postbus 65
8200 AB LELYSTAD, THE NETHERLANDS
Phone: 31-320-238651
Fax: 31-320-238668
24. Production of multidomain complement
glycoproteins in insect cells
Péter Závodszki and Sándor Cseh
Institute of Enzymology
Biological Research Center
Hungarian Academy of Sciences
P.O.
Box 7
H-1518 BUDAPEST, HUNGARY
Phone: 36-166-5633
Fax: 36-166-5465
E-mail: zxp @ enzim.hu
Part V: Economic and regulatory aspects
25. Economics and baculovirus-insect cell
production systems
David J. Rhodes
Zeneca Agrochemicals
Jealott’s Hill Research Station
Microbiology Section
BRACKNELL
Berkshire RG12 6EY, UNITED KINGDOM
Phone: 44-344-414201/424701
Fax: 44-344-414996
26. Safety aspects of insect culture
Glyn Stacey
1
and Robert D. Possee
2
1
European Collection of Animal Cell Cultures
Centre for Applied Microbiology & Research
PORTON DOWN, Salisbury
Wiltshire SP4 0JG, UNITED KINGDOM
Phone: 44-980-612512
Fax: 44-980-611315
E-mail: ecacc @ ecacc.demon.co.uk
2
NERC Institute of Virology and Environmental
Microbiology
Mansfield Road
OXFORD OX1 3SR, UNITED KINGDOM
Phone: 44-865-512361
Fax: 44-865-59962
E-mail: possee @ molbiol.ox.ac.uk
27. Regulatory issues in the use of insect cell
culture
Frank L.J. van Lier
Bio-Intermediar
Zuiderweg 72/2
P.O.
Box 454
9700 AL GRONINGEN, THE NETHERLANDS
Phone: 31-50-250405
Fax: 31-50-250609
Cytotechnology 20: 1996.
Key word index
Aedes albopticus 23
aggregation 149
airlift 211
airlift 233
amino acids 33
animal cell 233
applications 13
baculovirus 125
baculovirus 191
baculovirus 211
baculovirus 241
baculovirus 293
baculovirus 57
baculovirus expression 273
baculovirus expression system 101
baculovirus expression vector 101
baculovirus replication 95
baculovividae 73
bioreactor 191
bioreactors 125
bioreactors 173
bioreactors 211
biosafety 301
BiP 149
bubble column 211
bubble column 233
capsid proteins 263
cell differentiation 13
cell line establishment 3
cell-specific lines 13
characterization of 3
classical swine fever virus 273
containment 301
crossflow microfiltration 191
cryopreservation 3
CSTR 233
culture medium 57
design 233
development of 3
diagnostic tests 273
dihydrofolate reductase 23
dissolved oxygen 43
downstream processing 241
economics 293
energetics 33
envelope glycoproteins 273
fluidized bed 191
fluxes 33
folding 149
gene transfer 23
genomic alteration 125
growth 13
growth kinetics 43
immune response 263
insect cell culture
insect cell culture 241
insect cell culture 293
insect cell culture 43
insect cell culture 57
insect cell lines 145
insect cells
insect cells 163
insect cells 173
insect cells 211
insect cells 211
insect cells 263
insect cells 3
insect cells 3
insect cells 301
insect cells 33
insect tissue culture 13
isoenzymes 3
lepidopteran cell cultures 3
mathematical model 211
membrane perfusion 191
metabolic quotients 43
metabolism 33
mycoplasma 301
osmolality 43
oxygen gradients 233
oxygen uptake 33
packed bed 191
parameters 173
parvoviruses 263
passage 125
perfusion culture 191
pH 43
population balance 211
post-translational modification 139
production 145
production 173
production 293
protein disulfide isomerase 149
protein hydrolysate 57
protein production 149
proteins 139
purification 241
recombinant baculovirus 101
recombinant protein 57
recombinant protein production 191
recombinant proteins 145
respriation rates 43
risk 301
scale-up 211
scale-up 233
scale-up 241
scale-up 293
secretion 149
serum-free 57
shear 211
shear sensitivity 163
stirred veils 233
stirred vessel 211
subunit vaccines 273
survival 13
transgenic insect cells 23
viral fitness 125
viral interactions 73
viral persistence 125
virion 263
virus 301
VLPs 263