
HEALTH PHYSICS FUNDAMENTALS
545
The first step toward that task was the introduction of a factor called the
relative biological effectiveness (RBE), defined as
[absorbed dose from X-ray or gamma radiation (200-300 keV)
producing a certain biological effect]
RBEi
=
[absorbed dose from radiation type
i
producing the same biological effect]
In understanding the meaning of RBE, note the following:
1.
RBE is defined in terms of photons; therefore, it follows that RBE
=
1
for
electromagnetic radiation. Also, although the definition of RBE specifies the
energy of the photons to be 200-300 keV, RBE is taken as equal to
1
for
photons of all energies.
2.
A
given type of radiation does not have a single RBE, because RBE values
depend on the energy of the radiation, the cell, the biological effect being
studied, the total dose, dose rate, and other factors.
3. It is a well-known fact that the biological damage increases as the energy
deposited per unit distance, the
linear energy transfer
(LET), increases. Thus,
heavier particles (alphas, heavy ions, fission fragments) are, for the same
absorbed dose, more biologically damaging than photons, electrons, and
positrons.
In
1963,
the International Commission on Radiological Units and Measure-
ments (ICRU) proposed the replacement of RBE
by
a new factor named the
quality
factor
(QF).
Here is an excerpt from their recommendation.
In radiation protection it is necessary to provide a factor that denotes the modification of the
effectiveness of a given absorbed dose by
LET
(Linear Energy Transfer). Unlike
RBE,
which is
always experimentally determined, this factor
must
be
assigned
on the basis of a number of
considerations and it is recommended that it be termed the
quality factor
(QF).
Provisions for
other factors are also made. Thus a
distribution factor
(DF)
may be used to express the
modification of biological effect due to nonuniform distribution of internally deposited
radionuclides. The product of absorbed dose and modifying factors is termed the dose equiva-
lent,
(H).
In
1973
the
ICRU'
recommended dropping the "F" from QF, a suggestion
that has now become practice. In
1977
the
ICRP~
recommended that the dose
equivalent
(H)
at a point in tissue be written as
H
=
NQD
(16.6)
where
Q
=
quality factor
D
=
absorbed dose
N
=
product of all the modifying factors. The suggested value of
N
is
1.