Крыжановский С.А., Цорин И.Б. Рецептурный справочник с общей рецептурой
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РЕЦЕПТУРНЫЙ
СПРАВОЧНИК
С ОБЩЕЙ РЕЦЕПТУРОЙ
ÑÐÅÄÍÅÅ ÏÐÎÔÅÑÑÈÎÍÀËÜÍÎÅ ÎÁÐÀÇÎÂÀÍÈÅ
С.А.КРЫЖАНОВСКИЙ, И.Б.ЦОРИН
2
Êðûæàíîâñêèé Ñ.À.
Ðåöåïòóðíûé ñïðàâî÷íèê ñ îáùåé ðåöåïòóðîé : ó÷åá.
ïîñîáèå äëÿ ñòóä. ñðåä. ïðîô. ó÷åá. çàâåäåíèé / Ñ.À.Êðûæà-
íîâñêèé, È.Á.Öîðèí. Ì. : Èçäàòåëüñêèé öåíòð «Àêàäåìèÿ»,
2008. 368 ñ.
ISBN 978-5-7695-4980-9
Èçëîæåíû ïðàâèëà îôîðìëåíèÿ ðåöåïòîâ íà ðàçëè÷íûå ëåêàðñòâåí-
íûå ôîðìû ïðåïàðàòîâ. Ïðèâåäåíû ðåöåïòû íà âñå ïðåäñòàâëåííûå â ó÷åá-
íèêå Ñ. À.Êðûæàíîâñêîãî «Ôàðìàêîëîãèÿ» ëåêàðñòâåííûå ñðåäñòâà. Â ïðè-
ëîæåíèè äàíû îôèöèàëüíî óòâåðæäåííûå áëàíêè ðåöåïòîâ, èìåþùèõ
õîæäåíèå â ìåäèöèíñêèõ ó÷ðåæäåíèÿõ Ðîññèéñêîé Ôåäåðàöèè.
Äëÿ ñòóäåíòîâ ñðåäíèõ ìåäèöèíñêèõ ó÷åáíûõ çàâåäåíèé.
ÓÄÊ 351.77(075.32)
ÁÁÊ 52.81ÿ723
Ê85
ISBN 978-5-7695-4980-9
Ê85
ÓÄÊ 351.77(075.32)
ÁÁÊ 52.81ÿ723
© Êðûæàíîâñêèé Ñ. À., Öîðèí È. Á., 2008
© Îáðàçîâàòåëüíî-èçäàòåëüñêèé öåíòð «Àêàäåìèÿ», 2008
© Îôîðìëåíèå. Èçäàòåëüñêèé öåíòð «Àêàäåìèÿ», 2008
Îðèãèíàë-ìàêåò äàííîãî èçäàíèÿ ÿâëÿåòñÿ ñîáñòâåííîñòüþ
Èçäàòåëüñêîãî öåíòðà «Àêàäåìèÿ», è åãî âîñïðîèçâåäåíèå ëþáûì ñïîñîáîì
áåç ñîãëàñèÿ ïðàâîîáëàäàòåëÿ çàïðåùàåòñÿ
Ðåöåíçåíòû:
ïðåïîäàâàòåëü ôàðìàêîëîãèè Ìåäèöèíñêîãî ó÷èëèùà ¹ 3 ã. Ìîñêâû
Ë.Ñ.Áóäèëîâñêàÿ;
äîöåíò êàôåäðû ôàðìàêîëîãèè ôàêóëüòåòà ôóíäàìåíòàëüíîé ìåäèöèíû
ÌÃÓ èì. Ì.Â.Ëîìîíîñîâà Å.À.Ãîðîäåöêàÿ
351
ОГЛАВЛЕНИЕ
Ïðåäèñëîâèå ................................................................................................. 3
Ðåöåïòóðà ...................................................................................................... 5
ÐÀÇÄÅË I
ËÅÊÀÐÑÒÂÅÍÍÛÅ ÑÐÅÄÑÒÂÀ, ÂËÈßÞÙÈÅ
ÍÀ ÖÅÍÒÐÀËÜÍÛÅ È ÏÅÐÈÔÅÐÈ×ÅÑÊÈÅ
ÍÅÉÐÎÌÅÄÈÀÒÎÐÍÛÅ ÏÐÎÖÅÑÑÛ
Ãëàâà 1. Ëåêàðñòâåííûå ñðåäñòâà, âëèÿþùèå íà ïåðèôåðè÷åñêèå
íåéðîìåäèàòîðíûå ïðîöåññû ......................................................... 38
1.1. Ëåêàðñòâåííûå ñðåäñòâà, âëèÿþùèå íà àêòèâíîñòü
õîëèíåðãè÷åñêèõ ñèíàïñîâ ........................................................... 38
1.1.1. Ëåêàðñòâåííûå ñðåäñòâà, ñòèìóëèðóþùèå
õîëèíîðåöåïòîðû, õîëèíîìèìåòè÷åñêèå
ëåêàðñòâåííûå ñðåäñòâà ......................................................38
1.1.2. Ëåêàðñòâåííûå ñðåäñòâà, áëîêèðóþùèå
õîëèíîðåöåïòîðû, õîëèíîëèòèêè .................................43
1.2. Ëåêàðñòâåííûå ñðåäñòâà, âëèÿþùèå íà àêòèâíîñòü
àäðåíåðãè÷åñêèõ ñèíàïñîâ ........................................................... 53
1.2.1. Ëåêàðñòâåííûå ñðåäñòâà, ñòèìóëèðóþùèå
àäðåíîðåàêòèâíûå ðåöåïòîðû,
àäðåíîìèìåòèêè ..................................................................53
1.2.2. Ëåêàðñòâåííûå ñðåäñòâà, áëîêèðóþùèå
àäðåíîðåöåïòîðû, àäðåíîëèòèêè èëè
àäðåíîíåãàòèâíûå ëåêàðñòâåííûå ñðåäñòâà ......................59
1.3. Ëåêàðñòâåííûå ñðåäñòâà, âëèÿþùèå íà ôóíêöèîíàëüíóþ
àêòèâíîñòü ïóðèíåðãè÷åñêîé ñèñòåìû ........................................66
1.3.1. Ëåêàðñòâåííûå ñðåäñòâà, íåèçáèðàòåëüíî
ñòèìóëèðóþùèå Ð
1
-ïóðèíåðãè÷åñêèå ðåöåïòîðû,
íåñåëåêòèâíûå Ð
1
-àäåíîçèíîìèìåòèêè ............................. 66
1.3.2. Ëåêàðñòâåííûå ñðåäñòâà, ñòèìóëèðóþùèå
Ð
2
-ïóðèíåðãè÷åñêèå ðåöåïòîðû, íåñåëåêòèâíûå
Ð
2
-àäåíîçèíîìèìåòèêè .......................................................67
1.3.3. Ëåêàðñòâåííûå ñðåäñòâà, îïîñðåäîâàííî
ñòèìóëèðóþùèå Ð
1
-ïóðèíåðãè÷åñêèå ðåöåïòîðû,
íåïðÿìûå Ð
1
-àäåíîçèíîìèìåòèêè ..................................... 67
1.3.4. Ëåêàðñòâåííûå ñðåäñòâà, èçáèðàòåëüíî áëîêèðóþùèå
Ð
1
-ïóðèíåðãè÷åñêèå ðåöåïòîðû, ñåëåêòèâíûå
Ð
1
-àäåíîçèíîëèòèêè ............................................................68
352
1.4. Ëåêàðñòâåííûå ñðåäñòâà, âëèÿþùèå íà ïåðèôåðè÷åñêèå
ãèñòàìèíîâûå ðåöåïòîðû ............................................................. 69
1.4.1. Ëåêàðñòâåííûå ñðåäñòâà, íåèçáèðàòåëüíî
ñòèìóëèðóþùèå Ã
1
- è Ã
2
-ãèñòàìèíîâûå
ðåöåïòîðû, íåñåëåêòèâíûå
ãèñòàìèíîìèìåòèêè ............................................................ 69
1.4.2. Ëåêàðñòâåííûå ñðåäñòâà, ñòèìóëèðóþùèå
Ã
2
-ãèñòàìèíîâûå ðåöåïòîðû, ñåëåêòèâíûå
Ã
2
-ãèñòàìèíîìèìåòèêè ....................................................... 69
1.4.3. Ëåêàðñòâåííûå ñðåäñòâà, îïîñðåäîâàííî ñòèìóëèðóþùèå
ãèñòàìèíîâûå ðåöåïòîðû, íåïðÿìûå
ãèñòàìèíîìèìåòèêè ............................................................ 70
1.4.4. Ëåêàðñòâåííûå ñðåäñòâà, áëîêèðóþùèå
Ã
1
-ãèñòàìèíîâûå ðåöåïòîðû, ñåëåêòèâíûå
Ã
1
-ãèñòàìèíîëèòèêè ............................................................ 70
1.4.5. Ëåêàðñòâåííûå ñðåäñòâà, áëîêèðóþùèå
Ã
2
-ãèñòàìèíîâûå ðåöåïòîðû, ñåëåêòèâíûå
Ã
2
-ãèñòàìèíîëèòèêè ............................................................ 72
1.4.6. Ëåêàðñòâåííûå ñðåäñòâà, òîðìîçÿùèå âûñâîáîæäåíèå
ãèñòàìèíà è äðóãèõ ìåäèàòîðîâ àëëåðãèè ......................... 73
1.5. Ëåêàðñòâåííûå ñðåäñòâà, âëèÿþùèå
íà ïåðèôåðè÷åñêèå ñåðîòîíèíîâûå ðåöåïòîðû ......................... 75
1.5.1. Ëåêàðñòâåííûå ñðåäñòâà, íåèçáèðàòåëüíî
ñòèìóëèðóþùèå ñåðîòîíèíîâûå ðåöåïòîðû,
íåñåëåêòèâíûå ñåðîòîíèíîìèìåòèêè ................................75
1.5.2. Ëåêàðñòâåííûå ñðåäñòâà, èçáèðàòåëüíî ñòèìóëèðóþùèå
5ÍÒ
1Â
- è 5ÍÒ
1D
-ñåðîòîíèíîâûå ðåöåïòîðû,
ñåëåêòèâíûå
5ÍÒ
1Â
- è 5ÍÒ
1D
-ñåðîòîíèíîìèìåòèêè .............................. 75
1.5.3. Ëåêàðñòâåííûå ñðåäñòâà ñëîæíîãî ðåöåïòîðíîãî
ìåõàíèçìà äåéñòâèÿ, ðåàëèçóþùèå ñâîè ýôôåêòû
â òîì ÷èñëå è ïóòåì ñòèìóëÿöèè
5ÍÒ
1Â
- è 5ÍÒ
1D
-ñåðîòîíèíîâûõ ðåöåïòîðîâ .....................76
1.5.4. Ëåêàðñòâåííûå ñðåäñòâà, èçáèðàòåëüíî áëîêèðóþùèå
5ÍÒ
1
-ñåðîòîíèíîâûå ðåöåïòîðû, ñåëåêòèâíûå
5ÍÒ
1
-ñåðîòîíèíîëèòèêè ..................................................... 76
1.5.5. Ëåêàðñòâåííûå ñðåäñòâà, èçáèðàòåëüíî
áëîêèðóþùèå 5ÍÒ
2
-ñåðîòîíèíîâûå ðåöåïòîðû,
ñåëåêòèâíûå 5ÍÒ
2
-ñåðîòîíèíîëèòèêè............................... 77
1.5.6. Ëåêàðñòâåííûå ñðåäñòâà, èçáèðàòåëüíî áëîêèðóþùèå
5ÍÒ
3
-ñåðîòîíèíîâûå ðåöåïòîðû, ñåëåêòèâíûå
5ÍÒ
3
-ñåðîòîíèíîëèòèêè ..................................................... 77
Ãëàâà 2. Ëåêàðñòâåííûå ñðåäñòâà, âëèÿþùèå
íà öåíòðàëüíûå íåéðîìåäèàòîðíûå ïðîöåññû .............................. 78
2.1. Ñíîòâîðíûå ëåêàðñòâåííûå ñðåäñòâà .......................................... 78
2.1.1. Ïðîèçâîäíûå áàðáèòóðîâîé êèñëîòû ................................. 78
2.1.2. Ïðîèçâîäíûå áåíçîäèàçåïèíà ............................................ 79
353
2.1.3. Ïðîèçâîäíûå ÃÀÌÊ ............................................................80
2.1.4. Ïðîèçâîäíûå öèêëîïèððîëîíà ...........................................81
2.1.5. Ïðîèçâîäíûå èìèäàçîëïèðèäèíà .......................................81
2.1.6. Ïðîèçâîäíûå ïèïåðèäèíîäèîíà ......................................... 81
2.1.7. Ñíîòâîðíûå ëåêàðñòâåííûå ñðåäñòâà ðàçíûõ
õèìè÷åñêèõ ãðóïï ................................................................ 81
2.2. Ïñèõîòðîïíûå ëåêàðñòâåííûå ñðåäñòâà ...................................... 82
2.2.1. Ïñèõîëåïòè÷åñêèå ëåêàðñòâåííûå ñðåäñòâà
(ïñèõîëåïòèêè) .................................................................... 82
2.2.2. Ïñèõîàíàëåïòè÷åñêèå ëåêàðñòâåííûå ñðåäñòâà
(ïñèõîàíàëåïòèêè) .............................................................. 96
2.3. Àíàëåïòèêè .................................................................................. 107
2.3.1. Àíàëåïòè÷åñêèå ëåêàðñòâåííûå ñðåäñòâà,
ðåàëèçóþùèå ñâîè ýôôåêòû, âëèÿÿ íà ðàçíûå
îòäåëû ãîëîâíîãî ìîçãà .................................................... 107
2.3.2. Àíàëåïòè÷åñêèå ëåêàðñòâåííûå ñðåäñòâà,
ðåàëèçóþùèå ñâîè ýôôåêòû íà óðîâíå
ïðîäîëãîâàòîãî ìîçãà ........................................................ 107
2.3.3. Àíàëåïòè÷åñêèå ëåêàðñòâåííûå ñðåäñòâà,
ðåàëèçóþùèå ñâîè ýôôåêòû íà óðîâíå
ñïèííîãî ìîçãà .................................................................. 109
2.4. Àíòèêîíâóëüñàíòû ...................................................................... 109
2.4.1. Ïðîòèâîñóäîðîæíûå (ïðîòèâîýïèëåïòè÷åñêèå)
ëåêàðñòâåííûå ñðåäñòâà .................................................... 109
2.4.2. Ëåêàðñòâåííûå ñðåäñòâà, ïðèìåíÿåìûå äëÿ ëå÷åíèÿ
ïàðêèíñîíèçìà .................................................................. 113
ÐÀÇÄÅË II
ÀÍÀËÃÅÇÈÐÓÞÙÈÅ È ÎÁÅÇÁÎËÈÂÀÞÙÈÅ
ËÅÊÀÐÑÒÂÅÍÍÛÅ ÑÐÅÄÑÒÂÀ
Ãëàâà 3. Ëåêàðñòâåííûå ñðåäñòâà äëÿ îáùåé àíåñòåçèè ......................... 117
3.1. Ëåêàðñòâåííûå ñðåäñòâà äëÿ èíãàëÿöèîííîãî
íàðêîçà ........................................................................................ 117
3.1.1. Ãàçîîáðàçíûå ëåêàðñòâåííûå ñðåäñòâà ............................. 117
3.1.2. Ëåòó÷èå æèäêîñòè............................................................... 117
3.2. Ëåêàðñòâåííûå ñðåäñòâà äëÿ íåèíãàëÿöèîííîãî
íàðêîçà ........................................................................................ 118
3.2.1. Ïðîèçâîäíûå áàðáèòóðîâîé
êèñëîòû .............................................................................. 118
3.2.2. Ïðîèçâîäíûå áåíçîäèàçåïèíà .......................................... 119
3.2.3. Ëåêàðñòâåííûå ñðåäñòâà ðàçíûõ õèìè÷åñêèõ
ãðóïï................................................................................... 119
Ãëàâà 4. Ýòèëîâûé ñïèðò .......................................................................... 119
Ãëàâà 5. Ìåñòíîàíåñòåçèðóþùèå ëåêàðñòâåííûå ñðåäñòâà ..................... 120
5.1. Ëåêàðñòâåííûå ñðåäñòâà äëÿ òåðìèíàëüíîé àíåñòåçèè ............ 120
354
5.2. Ëåêàðñòâåííûå ñðåäñòâà äëÿ ðåãèîíàëüíîé
è èíôèëüòðàöèîííîé àíåñòåçèè ............................................... 121
5.3. Ëåêàðñòâåííûå ñðåäñòâà, ïðèìåíÿåìûå
äëÿ âñåõ âèäîâ ìåñòíîé àíåñòåçèè ............................................ 122
Ãëàâà 6. Àíàëãåçèðóþùèå ëåêàðñòâåííûå ñðåäñòâà ................................. 123
6.1. Ëåêàðñòâåííûå ñðåäñòâà ãðóïïû íàðêîòè÷åñêèõ
àíàëüãåòèêîâ ............................................................................... 123
6.1.1. Àãîíèñòû îïèîèäíûõ ðåöåïòîðîâ ..................................... 123
6.1.2. Àãîíèñòû-àíòàãîíèñòû îïèîèäíûõ ðåöåïòîðîâ .............. 125
6.1.3. ×àñòè÷íûå àãîíèñòû îïèîèäíûõ ðåöåïòîðîâ .................. 126
6.1.4. Íàðêîòè÷åñêèå àíàëüãåòèêè ñìåøàííîãî
äåéñòâèÿ ............................................................................. 126
6.1.5. Àíòàãîíèñòû îïèîèäíûõ ðåöåïòîðîâ ............................... 127
6.2. Íåíàðêîòè÷åñêèå àíàëüãåòèêè ................................................... 127
6.2.1. Àíàëüãåòèêè-àíòèïèðåòèêè ............................................... 127
6.2.2. Íåñòåðîèäíûå ïðîòèâîâîñïàëèòåëüíûå ëåêàðñòâåííûå
ñðåäñòâà .............................................................................. 129
6.3. Ðàçäðàæàþùèå ëåêàðñòâåííûå ñðåäñòâà.................................... 134
6.3.1. Ðàçäðàæàþùèå ñðåäñòâà ðàñòèòåëüíîãî
ïðîèñõîæäåíèÿ .................................................................. 134
6.3.2. Ðàçäðàæàþùèå ëåêàðñòâåííûå ñðåäñòâà æèâîòíîãî
ïðîèñõîæäåíèÿ .................................................................. 136
6.3.3. Ñèíòåòè÷åñêèå ðàçäðàæàþùèå ëåêàðñòâåííûå
ñðåäñòâà .............................................................................. 137
ÐÀÇÄÅË III
ËÅÊÀÐÑÒÂÅÍÍÛÅ ÑÐÅÄÑÒÂÀ, ÐÅÀËÈÇÓÞÙÈÅ
ÑÂÎÈ ÝÔÔÅÊÒÛ ÍÀ ÓÐÎÂÍÅ
ÝÍÄÎÊÐÈÍÍÎÉ ÑÈÑÒÅÌÛ
Ãëàâà 7. Ãîðìîíû ãèïîòàëàìóñà è ãèïîôèçà
è èõ ñèíòåòè÷åñêèå àíàëîãè ........................................................ 139
7.1. Ãîðìîíû ãèïîòàëàìî-àäåíîãèïîôèçàðíîé
ñèñòåìû ....................................................................................... 139
7.2. Ãîðìîíû ãèïîòàëàìî-íåéðîãèïîôèçàðíîé
ñèñòåìû ....................................................................................... 142
Ãëàâà 8. Ãîðìîíû ùèòîâèäíîé æåëåçû, èõ ñèíòåòè÷åñêèå àíàëîãè
è àíòàãîíèñòû .............................................................................. 144
8.1. Éîäñîäåðæàùèå ãîðìîíû ùèòîâèäíîé æåëåçû
è èõ ñèíòåòè÷åñêèå àíàëîãè ...................................................... 144
8.2. Ëåêàðñòâåííûå ñðåäñòâà, ïîäàâëÿþùèå ôóíêöèîíàëüíóþ
àêòèâíîñòü ùèòîâèäíîé æåëåçû ................................................ 144
8.3. Ãîðìîíû ùèòîâèäíîé è ïàðàùèòîâèäíîé æåëåç,
ïðèíèìàþùèå ó÷àñòèå â ðåãóëÿöèè îáìåíà êàëüöèÿ
è ôîñôîðà .................................................................................... 145
355
Ãëàâà 9. Ãîðìîíû ïîäæåëóäî÷íîé æåëåçû, èõ ñèíòåòè÷åñêèå àíàëîãè,
ãèïîãëèêåìè÷åñêèå ñèíòåòè÷åñêèå ëåêàðñòâåííûå
ñðåäñòâà ........................................................................................ 146
9.1. Ãîðìîíû ïîäæåëóäî÷íîé æåëåçû .............................................. 146
9.2. Ãèïîãëèêåìè÷åñêèå è ýóãëèêåìè÷åñêèå ëåêàðñòâåííûå
ñðåäñòâà äëÿ ïðèìåíåíèÿ per os ............................................... 147
9.2.1. Ãèïîãëèêåìè÷åñêèå ëåêàðñòâåííûå ñðåäñòâà
ïðîèçâîäíûå ñóëüôàíèëìî÷åâèíû .................................. 147
9.2.2. Ýóãëèêåìè÷åñêèå ëåêàðñòâåííûå ñðåäñòâà
áèãóàíèäû .......................................................................... 148
Ãëàâà 10. Ãîðìîíû êîðû íàäïî÷å÷íèêîâ,
èõ ñèíòåòè÷åñêèå àíàëîãè è àíòàãîíèñòû .................................. 148
10.1. Ìèíåðàëîêîðòèêîèäû è èõ ñèíòåòè÷åñêèå
àíàëîãè ........................................................................................ 148
10.2. Ãëþêîðòèêîñòåðîèäû è èõ ñèíòåòè÷åñêèå
àíàëîãè ........................................................................................ 149
10.2.1. Ãëþêîêîðòèêîñòåðîèäû ñèñòåìíîãî
äåéñòâèÿ ............................................................................. 149
10.2.2. Ãëþêîêîðòèêîñòåðîèäû äëÿ ìåñòíîãî
ïðèìåíåíèÿ ....................................................................... 152
10.3. Àíòàãîíèñòû ãëþêî-
è ìèíåðàëîêîðòèêîñòåðîèäîâ .................................................... 155
Ãëàâà 11. Ïîëîâûå ãîðìîíû, èõ ñèíòåòè÷åñêèå àíàëîãè
è àíòàãîíèñòû .............................................................................. 155
11.1. Æåíñêèå ïîëîâûå ãîðìîíû, èõ ñèíòåòè÷åñêèå àíàëîãè
è àíòàãîíèñòû ............................................................................. 155
11.1.1. Ýñòðîãåíû, èõ ñèíòåòè÷åñêèå àíàëîãè
è àíòèýñòðîãåííûå ëåêàðñòâåííûå
ñðåäñòâà .............................................................................. 155
11.1.2. Ãåñòàãåíû è èõ ñèíòåòè÷åñêèå àíàëîãè .......................... 158
11.2. Ìóæñêèå ïîëîâûå ãîðìîíû, èõ ñèíòåòè÷åñêèå àíàëîãè
è àíòàãîíèñòû ............................................................................. 160
11.3. Êîìáèíèðîâàííûå ëåêàðñòâåííûå ñðåäñòâà, ñîäåðæàùèå
ñèíòåòè÷åñêèå àíàëîãè ïîëîâûõ ãîðìîíîâ ............................... 161
11.3.1. Ïðîòèâîçà÷àòî÷íûå ãîðìîíàëüíûå
ëåêàðñòâåííûå ñðåäñòâà .................................................... 161
11.3.2. Êîìáèíèðîâàííûå ëåêàðñòâåííûå ñðåäñòâà,
ñîäåðæàùèå ñèíòåòè÷åñêèå àíàëîãè æåíñêèõ
è ìóæñêèõ ïîëîâûõ ãîðìîíîâ .......................................... 162
Ãëàâà 12. Àíàáîëè÷åñêèå ëåêàðñòâåííûå
ñðåäñòâà ........................................................................................ 163
Ãëàâà 13. Ëåêàðñòâåííûå ñðåäñòâà, ñîçäàííûå íà îñíîâå
ýéêîçàíîèäîâ, è èõ àíòàãîíèñòû ................................................ 164
356
ÐÀÇÄÅË IV
ËÅÊÀÐÑÒÂÅÍÍÛÅ ÑÐÅÄÑÒÂÀ, ÂËÈßÞÙÈÅ
ÍÀ ÔÓÍÊÖÈÎÍÀËÜÍÓÞ ÀÊÒÈÂÍÎÑÒÜ ÈÑÏÎËÍÈÒÅËÜÍÛÕ
ÑÈÑÒÅÌ
Ãëàâà 14. Ëåêàðñòâåííûå ñðåäñòâà, âëèÿþùèå íà ôóíêöèîíàëüíóþ
àêòèâíîñòü îðãàíîâ äûõàíèÿ ....................................................... 167
14.1. Ïðîòèâîêàøëåâûå ëåêàðñòâåííûå ñðåäñòâà ............................ 167
14.1.1. Íàðêîòè÷åñêèå ïðîòèâîêàøëåâûå ëåêàðñòâåííûå
ñðåäñòâà .............................................................................. 167
14.1.2. Íåíàðêîòè÷åñêèå ïðîòèâîêàøëåâûå
ëåêàðñòâåííûå ñðåäñòâà .................................................... 168
14.2. Îòõàðêèâàþùèå è ìóêîëèòè÷åñêèå
ëåêàðñòâåííûå ñðåäñòâà ............................................................. 169
14.2.1. Îòõàðêèâàþùèå ëåêàðñòâåííûå ñðåäñòâà ....................... 169
14.2.2. Ìóêîëèòè÷åñêèå ëåêàðñòâåííûå ñðåäñòâà ...................... 170
14.2.3. Ñóðôàêòàíòû ..................................................................... 173
14.3. Ëåêàðñòâåííûå ñðåäñòâà ñòèìóëÿòîðû äûõàíèÿ ................. 173
14.4. Áðîíõîëèòè÷åñêèå ëåêàðñòâåííûå ñðåäñòâà ............................ 174
Ãëàâà 15. Ëåêàðñòâåííûå ñðåäñòâà, âëèÿþùèå
íà ôóíêöèîíàëüíóþ àêòèâíîñòü ñåðäå÷íî-ñîñóäèñòîé
ñèñòåìû ........................................................................................ 174
15.1. Àíòèàðèòìè÷åñêèå ëåêàðñòâåííûå ñðåäñòâà ........................... 174
15.1.1. Àíòèàðèòìè÷åñêèå ëåêàðñòâåííûå ñðåäñòâà
I êëàññà ............................................................................... 174
15.1.2. Àíòèàðèòìè÷åñêèå ëåêàðñòâåííûå ñðåäñòâà
II êëàññà ............................................................................. 177
15.1.3. Àíòèàðèòìè÷åñêèå ëåêàðñòâåííûå ñðåäñòâà
III êëàññà ............................................................................ 177
15.1.4. Àíòèàðèòìè÷åñêèå ëåêàðñòâåííûå
ñðåäñòâà IV êëàññà ............................................................. 178
15.1.5. Äðóãèå ëåêàðñòâåííûå ñðåäñòâà, ïðèìåíÿåìûå
ïðè íàðóøåíèÿõ ðèòìà ñåðäöà ......................................... 179
15.2. Êàðäèîòîíè÷åñêèå ëåêàðñòâåííûå ñðåäñòâà ........................... 181
15.2.1. Ñåðäå÷íûå ãëèêîçèäû ...................................................... 181
15.2.2. Íåãëèêîçèäíûå êàðäèîòîíèêè ........................................ 182
15.3. Ëåêàðñòâåííûå ñðåäñòâà, âëèÿþùèå íà òîíóñ
ñîñóäîâ ......................................................................................... 184
15.3.1. Ëåêàðñòâåííûå ñðåäñòâà, ïîíèæàþùèå òîíóñ
ñîñóäèñòîé ñòåíêè ............................................................. 184
15.3.2. Ïðåïàðàòû, ïîâûøàþùèå òîíóñ
ñîñóäèñòîé ñòåíêè ............................................................. 192
15.4. Ëåêàðñòâåííûå ñðåäñòâà, óëó÷øàþùèå
ìåòàáîëèçì ìèîêàðäà ................................................................. 193
15.5. Ëåêàðñòâåííûå ñðåäñòâà, óëó÷øàþùèå êðîâîñíàáæåíèå
òêàíåé ìîçãà ................................................................................ 193
357
15.5.1. Ïðîèçâîäíûå ìåòèëêñàíòèíà .......................................... 193
15.5.2. Áëîêàòîðû êàëüöèåâûõ êàíàëîâ ...................................... 194
15.5.3. α-Àäðåíîáëîêàòîðû, ïðîèçâîäíûå àëêàëîèäîâ
ñïîðûíüè ............................................................................ 194
15.5.4. Ïðîèçâîäíûå íèêîòèíîâîé êèñëîòû .............................. 194
15.5.5. Ïðîèçâîäíûå ãëèêîçèäîâ áàðâèíêà ................................ 194
15.5.6. Ïðîèçâîäíûå ÃÀÌÊ ........................................................ 194
15.5.7. Ëåêàðñòâåííûå ñðåäñòâà
ðàçíûõ ãðóïï ...................................................................... 195
Ãëàâà 16. Ìî÷åãîííûå ëåêàðñòâåííûå ñðåäñòâà ...................................... 196
16.1. Ìî÷åãîííûå ëåêàðñòâåííûå ñðåäñòâà, äåéñòâóþùèå
â îáëàñòè ïðîêñèìàëüíîãî îòäåëà íåôðîíà ............................. 196
16.1.1. Èíãèáèòîðû êàðáîàíãèäðàçû .......................................... 196
16.1.2. Îñìîòè÷åñêèå ìî÷åãîííûå ëåêàðñòâåííûå
ñðåäñòâà .............................................................................. 196
16.2. Ìî÷åãîííûå ëåêàðñòâåííûå ñðåäñòâà, äåéñòâóþùèå
â îáëàñòè âîñõîäÿùåãî êîìïîíåíòà ïåòëè Ãåíëå .................... 197
16.3. Ìî÷åãîííûå ëåêàðñòâåííûå ñðåäñòâà, äåéñòâóþùèå
â îáëàñòè êîðòèêàëüíîãî ñåãìåíòà ïåòëè Ãåíëå ...................... 198
16.4. Ìî÷åãîííûå ëåêàðñòâåííûå ñðåäñòâà, äåéñòâóþùèå
â îáëàñòè äèñòàëüíîãî îòäåëà íåôðîíà,
êàëèéñáåðåãàþùèå äèóðåòèêè ................................................... 198
Ãëàâà 17. Ëåêàðñòâåííûå ñðåäñòâà, âëèÿþùèå
íà ôóíêöèîíàëüíîå ñîñòîÿíèå æåëóäî÷íî-êèøå÷íîãî
òðàêòà ........................................................................................... 199
17.1. Ëåêàðñòâåííûå ñðåäñòâà, ðåãóëèðóþùèå àïïåòèò .................. 199
17.1.1. Ëåêàðñòâåííûå ñðåäñòâà, ñòèìóëèðóþùèå
àïïåòèò ............................................................................... 199
17.1.2. Ëåêàðñòâåííûå ñðåäñòâà, ïîäàâëÿþùèå
àïïåòèò ............................................................................... 200
17.2. Ëåêàðñòâåííûå ñðåäñòâà, ðåàëèçóþùèå ñâîå äåéñòâèå
íà óðîâíå æåëóäêà ...................................................................... 201
17.2.1. Àíòàöèäíûå ëåêàðñòâåííûå ñðåäñòâà ............................. 201
17.2.2. Ëåêàðñòâåííûå ñðåäñòâà, ïîâûøàþùèå
ôóíêöèîíàëüíóþ àêòèâíîñòü æåëåç æåëóäêà .................. 203
17.2.3. Ëåêàðñòâåííûå ñðåäñòâà, ïîíèæàþùèå
ôóíêöèîíàëüíóþ àêòèâíîñòü æåëåç æåëóäêà .................. 204
17.2.4. Ãàñòðîïðîòåêòîðû ............................................................. 205
17.2.5. Ëåêàðñòâåííûå ñðåäñòâà, ïîâûøàþùèå
ìîòîðèêó æåëóäêà.............................................................. 206
17.3. Ëåêàðñòâåííûå ñðåäñòâà, âëèÿþùèå íà ìîòîðèêó
æåëóäî÷íî-êèøå÷íîãî òðàêòà .................................................... 207
17.3.1. Ëåêàðñòâåííå ñðåäñòâà, âûçûâàþùèå ðâîòó .................. 207
17.3.2. Ïðîòèâîðâîòíûå ëåêàðñòâåííûå ñðåäñòâà ...................... 208
17.3.3. Ñëàáèòåëüíûå ëåêàðñòâåííûå ñðåäñòâà .......................... 209
17.3.4. Ëåêàðñòâåííûå ñðåäñòâà äëÿ ëå÷åíèÿ äèàðåè ................ 211
358
17.4. Ëåêàðñòâåííûå ñðåäñòâà, ïðèìåíÿåìûå ïðè íàðóøåíèÿõ
ôèçèîëîãè÷åñêîé àêòèâíîñòè æåëåç êèøå÷íèêà ..................... 214
17.4.1. Ëåêàðñòâåííûå ñðåäñòâà, ïðèìåíÿåìûå ïðè ñíèæåíèè
ñåêðåòîðíîé àêòèâíîñòè êèøå÷íèêà ............................... 214
17.4.2. Ëåêàðñòâåííûå ñðåäñòâà, ïîäàâëÿþùèå
àêòèâíîñòü ïðîòåîëèòè÷åñêèõ ôåðìåíòîâ,
èíãèáèòîðû ïðîòåàç .......................................................... 215
17.5. Îáâîëàêèâàþùèå ëåêàðñòâåííûå ñðåäñòâà ............................. 216
17.6. Âÿæóùèå ëåêàðñòâåííûå ñðåäñòâà ........................................... 216
17.7. Âåòðîãîííûå ëåêàðñòâåííûå ñðåäñòâà ..................................... 220
17.8. Ëåêàðñòâåííûå ñðåäñòâà, âëèÿþùèå
íà ôóíêöèîíàëüíóþ àêòèâíîñòü ïå÷åíè ................................... 221
17.8.1. Æåë÷åãîííûå ëåêàðñòâåííûå ñðåäñòâà ........................... 221
17.8.2. Õîëåëèòîëèòè÷åñêèå ëåêàðñòâåííûå ñðåäñòâà ............... 223
17.8.3. Ãåïàòîïðîòåêòîðû ............................................................ 224
Ãëàâà 18. Ëåêàðñòâåííûå ñðåäñòâà, âëèÿþùèå
íà ñîêðàòèòåëüíóþ àêòèâíîñòü ìàòêè ........................................ 225
18.1. Òîêîìèìåòè÷åñêèå ëåêàðñòâåííûå ñðåäñòâà ........................... 225
18.2. Òîêîëèòè÷åñêèå ëåêàðñòâåííûå ñðåäñòâà ................................ 225
18.3. Óòåðîòîíè÷åñêèå ëåêàðñòâåíûå ñðåäñòâà ................................ 226
Ãëàâà 19. Ëåêàðñòâåííûå ñðåäñòâà, âëèÿþùèå íà ñèñòåìó
êðîâè ............................................................................................ 228
19.1. Ëåêàðñòâåííûå ñðåäñòâà, âëèÿþùèå íà ñèñòåìó
êðîâåòâîðåíèÿ ............................................................................. 228
19.1.1. Ëåêàðñòâåííûå ñðåäñòâà, âëèÿþùèå
íà ýðèòðîïîýç .................................................................... 228
19.1.2. Ëåêàðñòâåííûå ñðåäñòâà, âëèÿþùèå íà ëåéêîïîýç ....... 231
19.2. Ëåêàðñòâåííûå ñðåäñòâà, âëèÿþùèå íà ñâåðòûâàþùóþ
ñèñòåìó êðîâè ............................................................................. 237
19.2.1. Ëåêàðñòâåííûå ñðåäñòâà, ïîíèæàþùèå
ñâåðòûâàåìîñòü êðîâè ....................................................... 237
19.2.2. Ëåêàðñòâåííûå ñðåäñòâà, ïîâûøàþùèå
ñâåðòûâàåìîñòü êðîâè ....................................................... 240
19.3. Ïëàçìîçàìåùàþùèå è äåçèíòîêñèêàöèîííûå ðàñòâîðû ....... 244
19.3.1. Ãåìîäèíàìè÷åñêèå ðàñòâîðû ........................................... 244
19.3.2. Ðåãóëÿòîðû âîäíî-ñîëåâîãî áàëàíñà
(êðèñòàëëîèäû) .................................................................. 245
19.3.3. Äåçèíòîêñèêàöèîííûå ðàñòâîðû .................................... 246
Ãëàâà 20. Ëåêàðñòâåííûå ñðåäñòâà, ðåàëèçóþùèå ñâîè ýôôåêòû
íà óðîâíå èììóííîé ñèñòåìû ...................................................... 247
20.1. Ëåêàðñòâåííûå ñðåäñòâà, ïîäàâëÿþùèå èììóíîëîãè÷åñêèå
ðåàêöèè îðãàíèçìà ..................................................................... 247
20.1.1. Ëåêàðñòâåííûå ñðåäñòâà äëÿ ïðîôèëàêòèêè
è ëå÷åíèÿ ãèïåð÷óâñòâèòåëüíîñòè íåìåäëåííîãî
òèïà .................................................................................... 247