Chen C.C. (ed.) Selected Topics in DNA Repair
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SELECTED TOPICS IN
DNA REPAIR
Edited by Clark C. Chen
Selected Topics in DNA Repair
Edited by Clark C. Chen
Published by InTech
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Copyright © 2011 InTech
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First published October, 2011
Printed in Croatia
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Selected Topics in DNA Repair, Edited by Clark C. Chen
p. cm.
ISBN 978-953-307-606-5
free online editions of InTech
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Contents
Preface IX
Part 1 DNA Damaging Agents 1
Chapter 1 The DNA-Damage Response to
Ionizing Radiation in Human Lymphocytes 3
Maddalena Mognato, Mauro Grifalconi, Sabrina Canova,
Cristina Girardi and Lucia Celotti
Chapter 2 Interactions by Carcinogenic Metal
Compounds with DNA Repair Processes 29
Simona Catalani and Pietro Apostoli
Chapter 3 Effect of Oxidative Stress on DNA Repairing Genes 49
Bedia Cakmakoglu, Zeynep Birsu Cincin and Makbule Aydin
Chapter 4 UV Damaged DNA Repair & Tolerance in Plants 73
Ashwin L. Ganpudi and Dana F. Schroeder
Chapter 5 DNA Helix Destabilization by Alkylating Agents:
From Covalent Bonding to DNA Repair 97
Gaëlle Lenglet, Sabine Depauw,
Denise Mendy-Belaiche and Marie-Hélène David-Cordonnier
Chapter 6 DNA Damage Caused by Polycyclic
Aromatic Hydrocarbons: Mechanisms and Markers 125
Balam Muñoz and Arnulfo Albores
Chapter 7 DNA Repair: Lessons from the Evolution of Ionizing-
Radiation-Resistant Prokaryotes – Fact and Theory 145
Haïtham Sghaier
Chapter 8 Involvement of Non-Homologous End-Joining
in Radiation-Induced Genomic Instability 157
Keiji Suzuki, Motohiro Yamauchi, Masatoshi Suzuki,
Yasuyoshi Oka and Shunichi Yamashita
VI Contents
Part 2 Mechanistic Insights 173
Chapter 9 Role of RPA Proteins in Radiation Repair and Recovery 175
Patrick E. Gygli, J. Scott Lockhart and Linda C. DeVeaux
Chapter 10 Recognition and Repair Pathways
of Damaged DNA in Higher Plants 201
Sascha Biedermann, Sutton Mooney and Hanjo Hellmann
Chapter 11 DNA Damage Protection and Induction
of Repair by Dietary Phytochemicals and
Cancer Prevention: What Do We Know? 237
Alice A. Ramos, Cristóvão F. Lima and Cristina Pereira-Wilson
Chapter 12 The Nuclear Compartmentation of Glutathione:
Effect on Cell Cycle Progression 271
Jelena Markovic, Nancy Mora, Amparo Gimeno, Consuelo
Burguete, José Luis García-Gimenez and Federico V. Pallardó
Chapter 13 Role for PKCδ on Apoptosis
in the DNA Damage Response 293
Kiyotsugu Yoshida
Chapter 14 New Players in Recognition of Intact and Cleaved AP Sites:
Implication in DNA Repair in Mammalian Cells 305
Svetlana Khodyreva and Olga Lavrik
Part 3 Methods in DNA Repair 331
Chapter 15 SiDNA and Other Tools for the Indirect
Induction of DNA Damage Responses 333
Maria Quanz, Amélie Croset and Marie Dutreix
Chapter 16 DNA Repair in Pathogenic Eukaryotic Cells: Insights
from Comparative Genomics of Parasitic Protozoan 369
Laurence A. Marchat, Mavil López-Casamichana,
Esther Orozco and César López-Camarillo
Chapter 17 Mechanisms of Mutagenic DNA Nucleobase
Damages and Their Chemical and Enzymatic
Repairs Investigated by Quantum Chemical Methods 389
Eric A. C. Bushnell, Jorge Llano,
Leif A. Eriksson and James W. Gauld
Part 4 Insights into Therapeutic Strategies 415
Chapter 18 DNA Radiosensitization:
The Search for Repair Refractive Lesions Including
Double Strand Breaks and Interstrand Crosslinks 417
Tsvetan G. Gantchev, Marie-Eve Dextraze and Darel J. Hunting
Contents VII
Chapter 19 The Influence of Individual Genome Sensitivity in DNA
Damage Repair Assessment in Chronic Professional
Exposure to Low Doses of Ionizing Radiation 437
Mirta Milić, Ružica Rozgaj, Vilena Kašuba,
Ana Marija Jazbec, Patrizia Hrelia and Sabrina Angelini
Chapter 20 Application of Host Cell Reactivation in Evaluating the
Effects of Anticancer Drugs and Environmental Toxicants on
Cellular DNA Repair Activity in Head and Neck Cancer 465
Yi-Shan Tsai, Jau-Ling Huang and Chang-Shen Lin
Chapter 21 Role of Radioprotectors in the Inhibition
of DNA Damage and Modulation of DNA
Repair After Exposure to Gamma-Radiation 483
Dharmendra Kumar Maurya and Thomas Paul Asir Devasagayam
Chapter 22 DNA-Binding Radioprotectors 497
Pavel Lobachevsky, Alesia Ivashkevich,
Olga A. Martin and Roger F. Martin
Chapter 23 DNA Damage Response and Repair:
Insights into Strategies for Radiation Sensitization 519
Joshua D. Lawson, Kristopher T. Kahle, Kimberly Ng,
Bob Carter, Santosh Kesari and Clark C. Chen
Chapter 24 The Botanical Extract
Feverfew PFE Reduces DNA
Damage and Induces DNA Repair Processes 531
Michael D. Southall, Simarna Kaur and Khalid Mahmood
Chapter 25 Food Factors and Oxidative
DNA Damage / DNA Repair Systems 547
Takeshi Hirano and Kazuyoshi Tamae
Chapter 26 Enhancing DNA Repair by Combining only
Dietary Supplement Ingredients that do not
Metabolically Compete in Order to Achieve Synergism 561
Ronald W. Pero
Preface
In the past decades, we have seen rapid advancement in our fundamental
understanding of DNA repair, as well as translational application to medicine in
general. In this context, a comprehensive review of key concepts in DNA repair is well
beyond the scope of the presented text. Instead, select topics of pertinence to the field
are selected for presentation, with the goal of highlighting paradigmatic advances.
The selected articles are further meant to demonstrate how scientific ideas are
developed, tested, dialogued and matured, as it is meant to discuss key concepts in
DNA repair. It is my sincere hope that the articles presented will stimulate and inspire
thoughts that, in turn, contribute to a critically important field.
Clark C. Chen, M.D., Ph.D.
University of California, San Diego
USA