Berlin Heidelberg: Springer-Verlag, 2010. — 429 p. — ISBN
978-3-642-02111-4
Издание посвящено одной из наиболее привлекательных и
быстроразвивающихся тем в молекулярной биологии – внутриклеточной
передаче сигнала. Подробно освящены рецепторный аппарат для
различных типов регуляторных молекул, регуляторные киназы,
адапторные белки, транскрипционные факторы и т.д. Не обойдены
вниманием участие регуляторных путей в регуляции апоптоза, роста и
дифференциации клеток, митотического процесса. Прекрасно
представлена интеренснейшая тема роли свободных радикалов кислорода
во внутриклеточной сигнализации. Не забыты кальмодулин - и
убиквитинзависимые механизмы регуляции, роль конститутивной
активации рецепторного аппарата цитокинов в онкопатологии и т.п.
Особенно интересна глава посвященная модуляции пространственного
размещения А - киназ посредством анкерных(заякоривающих)
белков.
Издание заинтересует представителей разных специальностей:молекулярных биологов, биохимиков, иммунологов, цитологов ит.д. G Proteins and G Protein–Coupled Receptors
Traditional GPCR Pharmacology and Beyond
Regulation of Intraneuronal Trafficking of G-Protein-Coupled Receptors by Neurotransmitters In Vivo.
Small GTPases and Their Role in Regulating G Protein-Coupled Receptor Signal Transduction .
Regulation of G Protein Receptor Coupling, Mood Disorders and Mechanism of Action of Antidepressants.
Dysregulation of G Protein-Coupled Receptor Signaling in Cancer
Growth Factors
Insulin Signaling in Normal and Diabetic Conditions .
Epidermal Growth Factor (EGF) Receptor Signaling and Cancer.
Leptin Signaling Pathway.
Signaling in Normal and Pathological Angiogenesis.
Signaling Platforms
Spatial and Temporal Control of Cell Signaling by A-Kinase Anchoring Proteins
Mitochondria, a Platform for Diverse Signaling.
Mitogen-Activated Protein Kinases and Their Scaffolding Proteins.
Molecular and Functional Determinants of Ca2+ Signaling Microdomains.
Nuclear Receptors / Transcription
Eukaryotic Gene Transcription
Estrogen Signaling Mechanisms
Signal Transduction Pathways Involved in Glucocorticoid Actions.
Reactive Signaling Molecules
Cellular Signaling by Reactive Oxygen Species: Biochemical Basis and Physiological Scope.
Soluble Guanylyl Cyclase: The Nitric Oxide Receptor.
Cell Cycle, Cell Death and Cancer
Distinct Roles of the Pocket Proteins in the Control of Cell Cycle
Activation of the p53 Tumor Suppressor and its Multiple Roles in Cell Cycle and Apoptosis.
Aging and Cancer: Caretakers and Gatekeepers
Signal Transduction in Embryonic Stem Cells and the Rise of iPS Cells
Index
Издание заинтересует представителей разных специальностей:молекулярных биологов, биохимиков, иммунологов, цитологов ит.д. G Proteins and G Protein–Coupled Receptors
Traditional GPCR Pharmacology and Beyond
Regulation of Intraneuronal Trafficking of G-Protein-Coupled Receptors by Neurotransmitters In Vivo.
Small GTPases and Their Role in Regulating G Protein-Coupled Receptor Signal Transduction .
Regulation of G Protein Receptor Coupling, Mood Disorders and Mechanism of Action of Antidepressants.
Dysregulation of G Protein-Coupled Receptor Signaling in Cancer
Growth Factors
Insulin Signaling in Normal and Diabetic Conditions .
Epidermal Growth Factor (EGF) Receptor Signaling and Cancer.
Leptin Signaling Pathway.
Signaling in Normal and Pathological Angiogenesis.
Signaling Platforms
Spatial and Temporal Control of Cell Signaling by A-Kinase Anchoring Proteins
Mitochondria, a Platform for Diverse Signaling.
Mitogen-Activated Protein Kinases and Their Scaffolding Proteins.
Molecular and Functional Determinants of Ca2+ Signaling Microdomains.
Nuclear Receptors / Transcription
Eukaryotic Gene Transcription
Estrogen Signaling Mechanisms
Signal Transduction Pathways Involved in Glucocorticoid Actions.
Reactive Signaling Molecules
Cellular Signaling by Reactive Oxygen Species: Biochemical Basis and Physiological Scope.
Soluble Guanylyl Cyclase: The Nitric Oxide Receptor.
Cell Cycle, Cell Death and Cancer
Distinct Roles of the Pocket Proteins in the Control of Cell Cycle
Activation of the p53 Tumor Suppressor and its Multiple Roles in Cell Cycle and Apoptosis.
Aging and Cancer: Caretakers and Gatekeepers
Signal Transduction in Embryonic Stem Cells and the Rise of iPS Cells
Index