Lahann J. (ed.). Click Chemistry for Biotechnology and Materials Science

2009 John Wiley & Sons Ltd, 411 p.

Click Chemistry: A Universal Ligation Strategy for Biotechnology and Materials Science
Selected Examples of Click Reactions in Materials Science and Biotechnology
Potential Limitations of Click Chemistry
Common Synthons for Click Chemistry in Biotechnology
Peptides and Derivatives
Peptoids
Peptidic Dendrimers
Oligonucleotides
Carbohydrates
Copper-free Click Chemistry
Bio-orthogonal Ligations
Applications of Copper-free Click Chemistries
Protein and Peptide Conjugation to Polymers and Surfaces Using Oxime Chemistry
Protein/Peptide–Polymer Conjugates
Immobilization of Proteins and Peptides on Surfaces
The Role of Click Chemistry in Polymer Synthesis
Polymerization via CuAAC
Post-polymerization Modi?cation via Click Chemistry
Polymer–Biomacromolecule Conjugation
Functional Nanomaterials
Blocks, Stars and Combs: Complex Macromolecular Architecture Polymers via Click Chemistry
Block Copolymers
Star Polymers
Graft Copolymers
Concluding Remarks
Click Chemistry on Supramolecular Materials
Click Reactions on Rotaxanes, Cyclodextrines and Macrocycles
Click Reactions on DNA
Click Reactions on Supramolecular Polymers
Click Reactions on Membranes
Click Reactions on Dendrimers
Click Reactions on Gels and Networks
Click Reactions on Self-assembled Monolayers
Dendrimer Synthesis and Functionalization by Click Chemistry for Biomedical Applications
Dendrimer Synthesis
Dendrimer Functionalization
Conclusions and Future Directions
Reversible Diels–Alder Cycloaddition for the Design of Multifunctional Network Polymers
Design of Polymer Networks
Application of Diels–Alder Linkages to Polymer Systems
Click Chemistry in the Preparation of Biohybrid Materials
Polymer-containing Biohybrid Materials
Biohybrid Amphiphiles
Glycoconjugates
Functional Nanomaterials using the Cu-catalyzed Huisgen Cycloaddition Reaction
Inorganic Nanoparticles
Carbon-based Nanomaterials
Self-assembled Organic Structures
Virus Particles
Copper-catalyzed ‘Click’ Chemistry for Surface Engineering
Himabindu Nandivada and Joerg Lahann
Synthesis of Alkyne or Azide-functionalized Surfaces
Spatially Controlled Click Chemistry
Copper-catalyzed Click Chemistry for Bioimmobilization
Click Chemistry in Protein Engineering, Design, Detection and Pro?ling
Posttranslational Functionalization of Proteins with Azides and Alkynes
Cotranslational Functionalization of Proteins with Azides and Alkynes
BONCAT: Identi?cation of Newly Synthesized Proteins via Noncanonical Amino Acid Tagging
Conclusions and Future Prospects
Fluorogenic Copper(I)-catalyzed Azide–Alkyne Cycloaddition Reactions and their Applications in Bioconjugation
Click Reaction for Bioconjugation Applications
Signi?cance of Fluorogenic Reactions in Bioconjugation
CuAAC-based Fluorogenic Reaction
Applications of CuAAC in Bioconjugation
Synthesis and Functionalization of Biomolecules via Click Chemistry
Labeling of Macromolecular Biomolecules
Syntheses of Natural Products and Derivatives
Enzymes and Click Chemistry
Synthesis of Glycosylated Molecular Architectures
Synthesis of Nitrogen-rich Compounds: Polyazides and Triazoles
Unprecedented Electro-optic Properties in Polymers and Dendrimers Enabled by Click Chemistry Based on the Diels–Alder Reactions
Diels–Alder Click Chemistry for Highly Ef?cient Side-chain E-O Polymers
Diels–Alder Click Chemistry for Crosslinkable E-O Polymers Containing Binary NLO Chromophores
Diels–Alder Click Chemistry for NLO Dendrimers