Журнал - Reviews of Physiology, Biochemistry and Pharmacology. Vol 153. №153 (2005)

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of plasmids (Jakupec et al. 2002). Thus, the mechanisms by which KP776 and related

compounds exert their effects on malignant cells remain to be elucidated. Given the piv-

otal role of calcium signaling in controlling cell cycle and proliferation (Short et al. 1993;

Takuwa et al. 1995; Munaron et al. 2004) as well as malignant progression and angiogen-

esis (Kamrava et al. 2002), it seems reasonable to hypothesize a connection between the

capability of cerium to interfere with calcium-dependent processes and its antineoplastic

potential.

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