524 F. Peter Guengerich
1374.
Dwivedi, P.P., J.L. Omdahl, I. Kola, D.K. Hume,
and B.K. May (2000). Regulation of rat cyto-
chrome P450C24 (CYP24) gene expression. Evi-
dence for functional cooperation of Ras-activated
Ets transcription factors with the vitamin D
receptor in 1,25- dihydroxyvitamin D3-mediated
induction. J. Biol. Chem. 275, 47-55.
1375.
Raval-Pandya, M., P. Dhawan, F. Barletta, and
S. Christakos (2001). YYl represses vitamin D
receptor-mediated 25-hydroxyvitamin D3 24-
hydroxylase transcription: Relief of repression by
CREB-binding protein. Mol Endocrinol. 15,
1035-1046.
1376.
Dwivedi, PR, C.S. Hii, A. Ferrante, J. Tan,
C.J. Der, J.L. Omdahl et al (2002). Role of MAP
kinases in the 1,25-dihydroxyvitamin D^-induced
transactivation of the rat cytochrome P450C24
(CYP24) promoter. Specific functions for
ERK1/ERK2 and ERK5. J. Biol. Chem. Ill,
29643-29653.
1377.
Jones, G. and H.S. Tenenhouse (2002).
l,25(OH)2D, the preferred substrate for CYP24.
J. Bone
Miner.
Res. 17,
179-181.
1378.
Sakaki, T., N. Sawada, K. Komai, S. Shiozawa,
S. Yamada, K. Yamamoto et al. (2000). Dual
metabolic pathway of 25-hydroxyvitamin D3 cat-
alyzed by human CYP24. Eur J. Biochem. 267,
6158-6165.
1379.
Beckman, M.J., P Tadikonda, E. Werner, J. Prahl,
S. Yamada, and H.F DeLuca (1996). Human 25-
hydroxyvitamin D3-24-hydroxylase, a muhicat-
alytic enzyme. Biochemistry 35, 8465-8472.
1380.
Miyamoto, Y, T. Shinki, K. Yamamoto,
Y Ohyama, H. Iwasaki, R. Hosotani et
al.
(1997).
1 a,25-dihydroxyvitamin D3-24-hydroxylase
(CYP24) hydroxylates the carbon at the end of
the side chain (C-26) of the C-24-fluorinated ana-
log of la,25-dihydroxyvitamin
D3.
J.
Biol. Chem.
212, 14115-14119.
1381.
Hayashi, K., M. Akiyoshi-Shibata, T. Sakaki, and
Y Tabusaki (1998). Rat CYP24 catalyses 235"-
hydroxylation of 26,26,26,27,27,27-hexafluoro-
calcitriol in
vitro.
Xenobiotica 28, 457^63.
1382.
Sakaki, T, N. Sawada, Y Nonaka, Y Ohyama,
and K. Inouye (1999). Metabolic studies using
recombinant Escherichia coli cells producing rat
mitochondrial CYP24. CYP24 can convert
la,25-dihydroxyvitamin D3 to calcitroic acid.
Eur J. Biochem. 262, 43^8.
1383.
Inouye, K. and T. Sakaki (2001). Enzymatic
studies on the key enzymes of vitamin D metabo-
lism; la-hydroxylase (CYP27B1) and 24-hydrox-
ylase (CYP24).
Biotechnol.
Annu.
Rev.
7, 179-194.
1384.
Omdahl, J.L., E.V Bobrovnikova, A. Annalora,
P Chen, and R. Serda (2003). Expression,
structure-function, and molecular modeling of
vitamin D P450s. J. Cell. Biochem. 88, 356-362.
1385.
Dilworth, KJ., I. Scott, A. Green, S. Strugnell,
YD.
Guo, E.A. Roberts et al (1995). Different
mechanisms of hydroxylation site selection by
liver and kidney cytochrome P450 species
(CYP27 and CYP24) involved in vitamin D
metaboUsm. ^ 5zo/. Chem. 270, 16766-16774.
1386.
Schuster, I., H. Egger, P. Nussbaumer, and
R.T. Kroemer (2003). Inhibitors of vitamin D
hydroxylases: Structure-activity relationships.
J. Cell. Biochem. 88, 372-380.
1387.
Schuster, I., H. Egger, D. Bikle, G. Herzig,
G.S. Reddy, A. Stuetz et al. (2001). Selective
inhibition of vitamin D hydroxylases in human
keratinocytes. Steroids 66, 409-422.
1388.
Henry, H.L.
(2001).
The 25(OH)D3/la,25(OH)2D3-
24R-hydroxylase: A catabolic or biosynthetic
enzyme? Steroids 66, 391-398.
1389.
Kasuga, H., N. Hosogane, K. Matsuoka,
I. Mori, Y Sakura, K. Shimakawa et al. (2002).
Characterization of transgenic rats constitutively
expressing vitamin D-24-hydroxylase gene.
Biochem.
Biophys.
Res.
Commun.
297,1332-1338.
1390.
Martini, R. and M. Murray (1993). Participation
of P450 3A enzymes in rat hepatic microsomal
retinoic acid 4-hydroxylation. Arch. Biochem.
Biophys. 303, 57-66.
1391.
White, J.A., B. Beckett-Jones, YD. Guo,
F.J. Dilworth, J. Bonasoro, G. Jones et al.
(1997).
cDNA cloning of human retinoic acid-
metabolizing enzyme (hP450RAI) identifies
a novel family of cytochromes P450 (CYP26).
J. Biol. Chem. 272, 18539-18541.
1392.
White, J.A., H. Ramshaw, M. Taimi, W. Stangle,
A. Zhang, S. Everingham et al. (2000).
Identification of the human cytochrome P450,
P450RA1-2, which is predominantly expressed in
the adult cerebellum and is responsible for all-
trans-XQimo\c
acid metabolism. Proc. Natl.
Acad.
Sci. USA 97, 6403-6408.
1393.
Trofimova-Griffin, M.E. and M.R. Juchau (1998).
Expression of cytochrome P450RAI (CYP26) in
human fetal hepatic and cephalic tissues.
Biochem. Biophys. Res. Commun. 252,487-491.
1394.
Nelson, D.R. (1999). A second CYP26 P450 in
humans and zebrafish:
CYP26B1.
Arch.
Biochem.
Biophys. 371, 345-347.
1395.
Abu-Abed, S., G. MacLean, V Fraulob,
P Chambon, M. Petkovich, and P Dolle (2002).
Differential expression of the retinoic acid-
metabolizing enzymes CYP26A1 and CYP26B1
during murine organogenesis. Mech. Dev. 110,
173-177.
1396.
Trofimova-Griffin, M.E. and M.R. Juchau
(2002).
Developmental expression of cytochrome
CYP26B1 (P450RAI-2) in human cephalic
tissues. Brain. Res. Develop. Brain Res. 136,
175-178.