Plague had visited Rome in 1522, and had reduced its population to
55,000; murder, suicide, and flight must have reduced it below
40,000 in 1527; now, in July of that year, plague came back in the
full heat of summer, and joined with famine and the continued presence
of the ravaging horde to make Rome a city of horror, terror, and
desolation. Churches and streets were littered anew with corpses; many
of these were left to rot in the sun; the stench was so strong that
the jailers and prisoners fled from the castle parapets to their
rooms; even there many died of the infection, among them some servants
of the Pope. The impartial plague struck the invaders too; 2500
Germans in Rome died by July 22, 1527; and malaria, syphilis, and
malnutrition cut the horde in half.
The opponents of Charles began seriously to think of rescuing the
Pope. Henry VIII, fearing that an imprisoned pontiff might not grant
him a divorce from Catherine of Aragon, sent Cardinal Wolsey to France
to confer with Francis on measures to liberate Clement. Early in
August the two kings offered Charles peace and 2,000,000 ducats on
condition that the Pope and the French princes should be freed, and
that the Papal States should be restored to the Church. Charles
refused. By the treaty of Amiens (August 18) Henry and Francis pledged
themselves to war against Charles; soon Venice and Florence joined
this new league. French forces captured Genoa and Pavia, and sacked
the latter city almost as thoroughly as the imperialist army had
sacked Rome. Mantua and Ferrara, dreading the present French more than
the distant Charles, now joined the league. Nevertheless Lautrec,
the French commander, unable to pay his troops, dared not march upon
Rome.
The Emperor, hoping to restore his grace in Catholic Christendom,
and to cool the ardor of the growing league, agreed to release the
Pope, on condition that Clement should give no aid to the league,
should at once pay the imperialist army in Rome 112,000 ducats, and
should give hostages for his good behavior. Clement raised the money
by selling red hats, and by granting the Emperor a tenth of
ecclesiastical revenues in the Kingdom of Naples. On December 7, after
seven months of confinement, Clement left Sant' Angelo, and, disguised
as a servant, made his way humbly out of Rome to Orvieto, apparently a
broken man.