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Lednicer D., Mitscher L.A. The Organic Chemistry of Drug Synthesis, vol.1
New york - Chichester - Brisbane – Toronto: A Wiley-Interscience publication, 1977. -
472 p.
This book assumes a good working knowledge of the more common organic reactions and a rudimentary knowledge of biology. We hope it will be of interest to all organic chemists curious about therapeutic agents, how these were developed, the synthetic operations used in their preparation, and the types of structures that liave proven useful as drugs. We hope further that this long look ,it what has gone before may provide food for thought not only to the practicing medicinal chemist but also to the organic chemist engaged in research in pure synthetic chemistry.
A Case Study in Molecular Manipulation: The Local Anesthetics
Monocyclic Alicyclic Compounds
Benzyl and Benzhydryl Derivatives
Phenethyl and Phenylpropylamines
Arylacetic and Arylpropionic Acids
Arylethylenes and Their Reduction Products
Monocyclic Aromatic Compounds
Polycyclic Aromatic Compounds
Steroids
Tetracyclines
Acyclic Compounds
Five-Membered Heterocycles
Six-Membered Heterocycles
Derivatives of Morphine, Morphinan, and Benzomorphan; 4-Phenylpiperidines
Five-Membered Heterocycles Fused to One Benzene Ring
Six-Membered Heterocycles Fused to One Benzene Ring
BenzPhenothiazinesodiazepines
Additional Heterocycles Fused to Two Benzene Rings
?-Lactam Antibiotics
Miscellaneous Fused Heterocycles
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