Wiley-VCH. 2007. 564 p.
In this reference leaders at the forefront of research provide an insight into one of the hottest topics in organic synthesis, focusing on the most important enantioselective reactions. Clearly structured, each entry begins with a concise introduction, including a mechanistic discussion of the reaction, followed by preparative guidelines for newcomers, such as carefully selected working procedures with critical notes for bench chemists, rules of thumb and tips and tricks.
Contents
Asymmetric Organocatalysis: A New Stream in Organic Synthesis
Enamine Catalysis
Aldol and Mannich-Type Reactions
a-Heteroatom Functionalization
Direct Conjugate Additions via Enamine Activation
Iminium Catalysis
Ammonium Ions as Chiral Templates
Organocatalytic Enantioselective Morita–Baylis–Hillman (MBH) Reactions
Asymmetric Proton Catalysis
Chiral Lewis Bases as Catalysts
Asymmetric Acyl Transfer Reactions
Nucleophilic N-Heterocyclic Carbenes in Asymmetric Organocatalysis
Ylide-Based Reactions
Organocatalytic Enantioselective Reduction of Olefins, Ketones, and Imines
Oxidation Reactions
Shape- and Site-Selective Asymmetric Reactions
Appendix I: Reaction Procedures
Appendix II: Catalysts
In this reference leaders at the forefront of research provide an insight into one of the hottest topics in organic synthesis, focusing on the most important enantioselective reactions. Clearly structured, each entry begins with a concise introduction, including a mechanistic discussion of the reaction, followed by preparative guidelines for newcomers, such as carefully selected working procedures with critical notes for bench chemists, rules of thumb and tips and tricks.
Contents
Asymmetric Organocatalysis: A New Stream in Organic Synthesis
Enamine Catalysis
Aldol and Mannich-Type Reactions
a-Heteroatom Functionalization
Direct Conjugate Additions via Enamine Activation
Iminium Catalysis
Ammonium Ions as Chiral Templates
Organocatalytic Enantioselective Morita–Baylis–Hillman (MBH) Reactions
Asymmetric Proton Catalysis
Chiral Lewis Bases as Catalysts
Asymmetric Acyl Transfer Reactions
Nucleophilic N-Heterocyclic Carbenes in Asymmetric Organocatalysis
Ylide-Based Reactions
Organocatalytic Enantioselective Reduction of Olefins, Ketones, and Imines
Oxidation Reactions
Shape- and Site-Selective Asymmetric Reactions
Appendix I: Reaction Procedures
Appendix II: Catalysts